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High-fat diet consumption by male rat offspring of obese mothers exacerbates adipose tissue hypertrophy and metabolic alterations in adult life.
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- Author(s): Rodríguez-González, Guadalupe L.; De Los Santos, Sergio; Méndez-Sánchez, Dayana; Reyes-Castro, Luis A.; Ibáñez, Carlos A.; Canto, Patricia; Zambrano, Elena
- Source:
British Journal of Nutrition; 9/14/2023, Vol. 130 Issue 5, p783-792, 10p- Subject Terms:
OBESITY complications; BLOOD sugar analysis; MOTHERS; LACTATION; THERAPEUTICS; TRIGLYCERIDES; ADRENOCORTICAL hormones; BODY weight; ANIMAL experimentation; LEPTIN; METABOLIC disorders; INSULIN; PUERPERIUM; FAT cells; RESEARCH funding; DIETARY fats; ADIPOSE tissues; INSULIN resistance; DISEASE risk factors - Source:
- Additional Information
- Abstract: Obese mothers' offspring develop obesity and metabolic alterations in adulthood. Poor postnatal dietary patterns also contribute to obesity and its comorbidities. We aimed to determine whether in obese mothers' offspring an adverse postnatal environment, such as high-fat diet (HFD) consumption (second hit) exacerbates body fat accumulation, metabolic alterations and adipocyte size distribution. Female Wistar rats ate chow (C-5 %-fat) or HFD (maternal obesity (MO)-25 %-fat) from weaning until the end of lactation. Male offspring were weaned on either control (C/C and MO/C, maternal diet/offspring diet) or HFD (C/HF and MO/HF) diet. At 110 postnatal days, offspring were killed. Fat depots were excised to estimate adiposity index (AI). Serum glucose, triglyceride, leptin, insulin, insulin resistance index (HOMA-IR), corticosterone and dehydroepiandrosterone (DHEA) were determined. Adipocyte size distribution was evaluated in retroperitoneal fat. Body weight was similar in C/C and MO/C but higher in C/HF and MO/HF. AI, leptin, insulin and HOMA-IR were higher in MO/C and C/HF v. C/C but lower than MO/HF. Glucose increased in MO/HF v. MO/C. C/HF and MO/C had higher triglyceride and corticosterone than C/C, but lower corticosterone than MO/HF. DHEA and the DHEA/corticosterone ratio were lower in C/HF and MO/C v. C/C, but higher than MO/HF. Small adipocyte proportion decreased while large adipocyte proportions increased in MO/C and C/HF v. C/C and exacerbated in MO/HF v. C/HF. Postnatal consumption of a HFD by the offspring of obese mothers exacerbates body fat accumulation as well as the decrease of small and the increase of large adipocytes, which leads to larger metabolic abnormalities. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of British Journal of Nutrition is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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