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Plasma interleukin-6 levels are increased in subjects with impaired glucose tolerance but not in those with impaired fasting glucose in a cohort of Italian Caucasians.
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- Author(s): Cardellini M;Cardellini M; Andreozzi F; Laratta E; Marini MA; Lauro R; Hribal ML; Perticone F; Sesti G
- Source:
Diabetes/metabolism research and reviews [Diabetes Metab Res Rev] 2007 Feb; Vol. 23 (2), pp. 141-5.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883450 Publication Model: Print Cited Medium: Print ISSN: 1520-7552 (Print) Linking ISSN: 15207552 NLM ISO Abbreviation: Diabetes Metab Res Rev Subsets: MEDLINE
- Publication Information: Original Publication: Oxford, England : Wiley-Blackwell, c1999-
- Subject Terms: Diabetes Mellitus, Type 2/*blood ; Glucose Intolerance/*blood ; Interleukin-6/*blood; Adolescent ; Adult ; Aged ; Blood Glucose/analysis ; Cohort Studies ; Fasting ; Female ; Humans ; Italy ; Male ; Middle Aged ; White People
- Abstract: Background: While the relationship between impaired glucose tolerance (IGT) and circulating interleukin-6 (IL-6) is well established, there is no information whether IL-6 levels are elevated in impaired fasting glucose (IFG).
Methods: To this end, we examined the relationship between plasma IL-6 concentration and different degrees of glucose homeostasis in a cohort of 470 Italian Caucasian subjects comprising 236 normal glucose tolerant (NGT), 49 IFG, 51 IGT, and 134 type 2 diabetic subjects.
Results: We observed that IL-6, CRP and fibrinogen levels were higher in subjects with IGT or type 2 diabetes as compared with NGT and IFG subjects. Univariate correlations between IL-6 concentrations and metabolic variables in the whole cohort showed that IL-6 levels were positively correlated with age, BMI, waist, systolic and diastolic blood pressure, fasting plasma glucose, triglycerides, CRP, fibrinogen, and negatively correlated with insulin sensitivity, IGF-I and HDL. In a subgroup analysis including NGT, IFG and IGT (n = 336), IL-6 levels were positively correlated with age, BMI, waist, systolic and diastolic blood pressure, triglycerides, CRP, fibrinogen, fasting insulin, 2 h post-load glucose, and negatively correlated with insulin sensitivity, IGF-I and HDL. Stepwise linear regression analysis in a model including gender, age, BMI, waist, glucose tolerance status, fasting plasma glucose, 2 h post-load glucose, triglycerides, HDL, fasting insulin, and insulin sensitivity revealed that waist was the only independent variable associated with IL-6 levels accounting for 21.0% of its variation (P < 0.0001).
Conclusions: These data show that IGT and type 2 diabetes, but not IFG, are associated with elevated plasma IL-6 levels.
(Copyright 2006 John Wiley & Sons, Ltd.) - Accession Number: 0 (Blood Glucose)
0 (Interleukin-6) - Publication Date: Date Created: 20060905 Date Completed: 20070406 Latest Revision: 20221207
- Publication Date: 20231215
- Accession Number: 10.1002/dmrr.679
- Accession Number: 16952201
- Source:
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