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Persistent infection with and serologic cross-reactivity of three novel murine noroviruses.
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- Author(s): Hsu CC;Hsu CC; Riley LK; Wills HM; Livingston RS
- Source:
Comparative medicine [Comp Med] 2006 Aug; Vol. 56 (4), pp. 247-51.
- Publication Type:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: American Association for Laboratory Animal Science Country of Publication: United States NLM ID: 100900466 Publication Model: Print Cited Medium: Print ISSN: 1532-0820 (Print) Linking ISSN: 15320820 NLM ISO Abbreviation: Comp Med Subsets: MEDLINE
- Publication Information:
Original Publication: Memphis, TN : American Association for Laboratory Animal Science, 2000-
- Subject Terms:
- Abstract:
According to serologic testing, murine norovirus is the most prevalent viral pathogen in contemporary laboratory mice. Previously, murine norovirus 1 (MNV-1) was the only norovirus reported to infect research mice. In this study, 3 novel murine norovirus strains--MNV-2, MNV-3, and MNV-4--were isolated from geographically separate mouse research colonies. All 4 murine norovirus strains used as individual antigens in microsphere fluorescent immunoassays displayed serologic cross-reactivity to serum from mice inoculated with MNV-1, MNV-2, MNV-3, or MNV-4. In addition, reverse transcriptase-polymerase chain reaction analysis at 8 wk postinoculation detected virus in the feces and tissues of all mice experimentally inoculated with MNV-2, MNV-3, or MNV-4. This finding suggests that mice can have prolonged fecal shedding of and can become persistently infected with murine noroviruses.
- Grant Information:
2 U42 RR014821 United States RR NCRR NIH HHS; T32-RR07004 United States RR NCRR NIH HHS; U54 AI057160 United States AI NIAID NIH HHS
- Accession Number:
0 (Antigens, Viral)
0 (RNA, Viral)
- Publication Date:
Date Created: 20060901 Date Completed: 20060928 Latest Revision: 20210412
- Publication Date:
20231215
- Accession Number:
16941951
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