Regulation of the hypertonic stress response and other cellular functions by the Rel-like transcription factor NFAT5.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-2952 (Print) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Elsevier Science
      Original Publication: Oxford, New York [etc.] Paragamon Press.
    • Subject Terms:
      Adaptation, Physiological* ; Gene Expression Regulation*; NFATC Transcription Factors/*genetics ; Transcription Factor RelB/*genetics ; Transcription Factors/*genetics; Amino Acid Sequence ; Animals ; Humans ; Mice ; Mice, Knockout ; Molecular Sequence Data ; NFATC Transcription Factors/metabolism ; Osmotic Pressure ; Sequence Alignment ; Transcription Factor RelB/metabolism ; Transcription Factors/metabolism
    • Abstract:
      Stress, be it from environmental factors or intrinsic to the cell as result of growth and metabolism, can be harmful to cells. Mammalian cells have developed numerous mechanisms to respond to diverse forms of stress. These mechanisms combine signaling cascades and activation of gene expression programs to orchestrate an adaptive response that will allow the cell to survive and resume its normal functioning. In this review we will focus on the transcription factor NFAT5, a fundamental regulator of the response to osmotic stress in mammalian cells. Identified in 1999, NFAT5 is the latest addition to the Rel family, which comprises the NF-kappaB and NFATc proteins. Though in some of its structural and functional features NFAT5 is a hybrid between these two major groups of Rel proteins, it has unique characteristics that make it stand on its own as a third type of Rel transcription factor. Since its discovery, NFAT5 has been studied mostly in the context of the hypertonicity stress response. The advent of mouse models deficient in NFAT5 and other recent advances have confirmed a fundamental osmoprotective role for this factor in mammals, but also revealed features that suggest it may have a wider range of functions.
    • Number of References:
      53
    • Molecular Sequence:
      GENBANK AAC50887; AAD38630; AAG28468; Q00653
    • Accession Number:
      0 (NFAT5 protein, human)
      0 (NFATC Transcription Factors)
      0 (Transcription Factors)
      147337-75-5 (Transcription Factor RelB)
    • Publication Date:
      Date Created: 20060815 Date Completed: 20070104 Latest Revision: 20061107
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.bcp.2006.07.002
    • Accession Number:
      16904650