[Production of interferon-gamma and interleukin-10 by splenic cells of mice infected with Toxoplasma gondii or immunized with antigens of killed parasites].

Wytwarzanie interferonu-gamma i interleukiny-10 przez komórki sledzionowe myszy zarazonych Toxoplasma gondii lub immunizowanych antygenem zabitych pasozytów.

Publisher: Polskie Towarzystwo Parazytologiczne Country of Publication: Poland NLM ID: 0420554 Publication Model: Print Cited Medium: Print ISSN: 0043-5163 (Print) Linking ISSN: 00435163 NLM ISO Abbreviation: Wiad Parazytol Subsets: MEDLINE

Publication: <2000>- : Warszawa : Polskie Towarzystwo Parazytologiczne
Original Publication: Warszawa : Panstwowe Wydawnictwo Naukowe

Interferon-gamma/*biosynthesis ; Interleukin-10/*biosynthesis ; Spleen/*immunology ; T-Lymphocytes/*immunology ; Toxoplasma/*immunology ; Toxoplasmosis, Animal/*immunology; Animals ; Antigens, Protozoan/immunology ; Antigens, Protozoan/isolation & purification ; Cells, Cultured ; Immunization/methods ; Lymphocyte Activation ; Macrophages/immunology ; Mice ; Mice, Inbred Strains ; Toxoplasma/isolation & purification ; Toxoplasmosis, Animal/prevention & control ; Vaccines, Inactivated

Splenic lymphocytes from T. gondii infected mice produced high levels of IFN-gamma in vitro. The production of IFN-gamma was increasing until 10-th day of infection, reaching a level 1600-fold higher to that found in control cultures, then it began to decrease. The level of IL-10 released by lymphocytes to the medium was also increasing up to the 10-th day of infection, afterwards its content dropped down to the level 18-fold higher than that at the beginning of experiments. There were no effects of immunization with antigens of killed parasites on the production of IFN-gamma by splenic cells in vitro.

0 (Antigens, Protozoan)
0 (Vaccines, Inactivated)
130068-27-8 (Interleukin-10)
82115-62-6 (Interferon-gamma)

Date Created: 20060811 Date Completed: 20061002 Latest Revision: 20081121

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