[Autologous bone marrow stem cell or peripheral blood endothelial progenitor cell therapy in patients with peripheral limb ischaemia].

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  • Author(s): Boda Z;Boda Z; Veréb Z; Rajnavölgyi E
  • Source:
    Orvosi hetilap [Orv Hetil] 2006 Jun 25; Vol. 147 (25), pp. 1155-60.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Hungarian
  • Additional Information
    • Transliterated Title:
      Elorehaladott perifériás artériás érbetegségben szenvedok kezelése autológ csontveloi, vagy perifériás vérbol származó ossejtekkel.
    • Source:
      Publisher: Akademiai Kiado Country of Publication: Hungary NLM ID: 0376412 Publication Model: Print Cited Medium: Print ISSN: 0030-6002 (Print) Linking ISSN: 00306002 NLM ISO Abbreviation: Orv Hetil Subsets: MEDLINE
    • Publication Information:
      Publication: 2007- : Budapest : Akademiai Kiado
      Original Publication: Pest : Markusovszky Lajos
    • Subject Terms:
      Bone Marrow Transplantation* ; Endothelial Cells*; Arterial Occlusive Diseases/*surgery ; Extremities/*blood supply ; Ischemia/*etiology ; Ischemia/*surgery; Arterial Occlusive Diseases/complications ; Clinical Trials as Topic ; Humans ; Neovascularization, Physiologic ; Transplantation, Autologous ; Treatment Outcome
    • Abstract:
      No effective medical therapies have been developed sofar to enhance blood flow in the legs of patients with peripheral arterial disease (PAD). For patients with limb threatening ischaemia the only option for relief of rest pain or gangraena is amputation. There is evidence in experimental and clinical studies that adult bone marrow-derived stem cells and endothelial progenitor cells participate in the development of new blood vessels, called neoangiogenesis or neovascularization. Clinical results induced by autologous bone marrow stem cells or angiogenic growth/differentiation factors in end-stage patients with PAD are summarized. Considering the relatively few number of patients treated by angiogenic therapy, the interpretation of clinical results needs cautiousness.
    • Number of References:
      30
    • Publication Date:
      Date Created: 20060809 Date Completed: 20060919 Latest Revision: 20091021
    • Publication Date:
      20240829
    • Accession Number:
      16893130