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Degenerative changes induced by paradoxical sleep deprivation in rat sublingual glands.
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- Author(s): de Aguiar, Gabriel Carvalhal; Souza, Ana Carolina Flygare; de Souza, Daniel Vitor; Neto, Marcos Monico; Le Sueur-Maluf, Luciana; de Moraes Malinverni, Andrea Cristina; Antunes, Hanna Karen Moreira; Ribeiro, Daniel Araki
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European Archives of Oto-Rhino-Laryngology; Sep2023, Vol. 280 Issue 9, p4261-4269, 9p- Subject Terms:
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- Abstract: Purpose: The aim of this study was to evaluate whether sleep deprivation can induce degenerative changes in rat sublingual glands. Methods: For this purpose, a total of 24 males were distributed into three groups: control (n = 8), in which the animals were not subjected to any procedure; sleep deprivation (n = 8) in which the animals were submitted to sleep deprivation for 96 h; recovery (n = 8), in which the animals were subjected to paradoxical sleep deprivation for 96 consecutive hours followed by 96 h without intervention. Morphological changes in sublingual glands as well as the immunoexpressions of some proteins, such as Ki-67, p16, cleaved caspase-3 and BCL-2 were investigated in this setting. Results: The results showed that paradoxical sleep deprivation induced tissue degeneration as a result of the presence of pyknosis, vacuoles and areas of salivary retention, in the experimental groups. Expression of cleaved caspase 3 and BCL-2 were increased in both sleep deprivation and recovery groups. The analysis of Ki-67 showed an increase in expression only in the recovery group, associated with a decrease in p16 levels. Conclusion: Sleep deprivation can induce a degenerative process in the parenchyma of sublingual gland by means of dysregulation of apoptosis associated with proliferative activity. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Archives of Oto-Rhino-Laryngology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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