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Structure of human MIP-3alpha chemokine.
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- Author(s): Malik ZA;Malik ZA; Tack BF
- Source:
Acta crystallographica. Section F, Structural biology and crystallization communications [Acta Crystallogr Sect F Struct Biol Cryst Commun] 2006 Jul 01; Vol. 62 (Pt 7), pp. 631-4. Date of Electronic Publication: 2006 Jun 30.
- Publication Type:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
- Language:
English
- Additional Information
- Source:
Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101226117 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-3091 (Electronic) Linking ISSN: 17443091 NLM ISO Abbreviation: Acta Crystallogr Sect F Struct Biol Cryst Commun Subsets: MEDLINE
- Publication Information:
Publication: Oxford, England : Wiley-Blackwell
Original Publication: Chester, England : International Union of Crystallography, c2005-
- Subject Terms:
- Abstract:
The structure of the human macrophage inflammatory protein-3alpha (MIP-3alpha) has been determined at 1.81 angstroms resolution by X-ray crystallography. The dimer crystallized in the tetragonal space group I4, with unit-cell parameters a = b = 83.99, c = 57.20 angstroms. The crystals exhibit two molecules in the asymmetric unit. The structure was solved by the molecular-replacement method and the model was refined to a conventional R value of 20.6% (R(free) = 25.7%). MIP-3alpha possesses the same monomeric structure as previously described for other chemokines. However, in addition to limited structural changes in the beta1-beta2 hairpin of monomer B, the electron density is fully defined for a few extra residues at the N- and C-termini of monomer A and the C-terminus of monomer B compared with MIP-3alpha in space group P6(1). As the N-terminal and loop regions have been shown to be critical for receptor binding and signaling, this additional structural information may help in determining the basis of the CCR6 selectivity of MIP-3alpha.
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- Molecular Sequence:
PDB 2HCI
- Accession Number:
0 (CCL20 protein, human)
0 (CCR6 protein, human)
0 (Chemokine CCL20)
0 (Chemokines, CC)
0 (Macrophage Inflammatory Proteins)
0 (Receptors, CCR6)
0 (Receptors, Chemokine)
- Publication Date:
Date Created: 20060706 Date Completed: 20060809 Latest Revision: 20240511
- Publication Date:
20240511
- Accession Number:
PMC2242953
- Accession Number:
10.1107/S1744309106006890
- Accession Number:
16820679
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