Impact of dopamine or dobutamine infusions on cardiovascular variables after rapid blood loss and volume replacement during isoflurane-induced anesthesia in dogs.

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  • Author(s): Dyson DH;Dyson DH; Sinclair MD
  • Source:
    American journal of veterinary research [Am J Vet Res] 2006 Jul; Vol. 67 (7), pp. 1121-30.
  • Publication Type:
    Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Veterinary Medical Association Country of Publication: United States NLM ID: 0375011 Publication Model: Print Cited Medium: Print ISSN: 0002-9645 (Print) Linking ISSN: 00029645 NLM ISO Abbreviation: Am J Vet Res Subsets: MEDLINE
    • Publication Information:
      Publication: Schaumburg, Ill. : American Veterinary Medical Association
      Original Publication: Chicago : American Veterinary Medical Assn.
    • Subject Terms:
      Blood Pressure/*drug effects ; Dobutamine/*pharmacology ; Dog Diseases/*drug therapy ; Dopamine/*pharmacology ; Hypovolemia/*veterinary ; Isoflurane/*pharmacology; Anesthetics, Inhalation/therapeutic use ; Animals ; Cardiotonic Agents/therapeutic use ; Dobutamine/administration & dosage ; Dobutamine/therapeutic use ; Dogs ; Dopamine/administration & dosage ; Dopamine/therapeutic use ; Dose-Response Relationship, Drug ; Female ; Heart Rate/drug effects ; Hypovolemia/drug therapy ; Male
    • Abstract:
      Objective: To determine the cardiovascular effects of dopamine and dobutamine infusions during nor-movolemia, hypovolemia (HV) through blood loss of 10 mL/kg (HV(10)), further loss to 25 mL/kg (HV(25)), and volume replacement (VR) in isoflurane-anesthetized dogs.
      Animals: 7 healthy young dogs.
      Procedures: Dogs were anesthetized with isoflurane 2 times (3 weeks apart). Cardiovascular measurements were obtained for each volume state. The cardiac index (CI) determined by the lithium dilution technique was compared with CI assessed by the arterial pulse contour technique. At each volume state, random treatment with dobutamine or dopamine was assessed (CI by the arterial pulse contour technique). Ten-minute treatments with 3 and 6 microg of dobutamine/kg/min or 7 and 14 microg of dopamine/kg/min (low and high doses, respectively) were administered sequentially. Differences from baseline were determined for volume, drug, and dose effects.
      Results: Significant proportional changes in blood pressure (BP), stroke index (SI), and CI were evident with changes in volume state. Systemic vascular resistance (SVR) decreased after VR. Dobutamine induced little change in BP; increased heart rate (HR), SI, and CI; and decreased SVR (high dose). Dopamine increased BP and SI, did not change CI, and increased SVR (high dose). The arterial pulse contour technique underestimated changes in CI associated with volume changes.
      Conclusions and Clinical Relevance: Isoflurane eliminates clinically obvious compensatory increases in HR during HV. Dopamine is suitable for temporary management of blood loss in isoflurane-anesthetized dogs. Dobutamine increased CI without an associated improvement in BP. The arterial pulse contour monitor should be recalibrated when volume status changes.
    • Accession Number:
      0 (Anesthetics, Inhalation)
      0 (Cardiotonic Agents)
      3S12J47372 (Dobutamine)
      CYS9AKD70P (Isoflurane)
      VTD58H1Z2X (Dopamine)
    • Publication Date:
      Date Created: 20060705 Date Completed: 20060912 Latest Revision: 20131121
    • Publication Date:
      20221213
    • Accession Number:
      10.2460/ajvr.67.7.1121
    • Accession Number:
      16817731