Ether lipids as anticancer agents: focus on non-phosphorus cationic glycerolipids.

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  • Author(s): Plyavnik NV;Plyavnik NV; Shtil AA; Serebrennikova GA
  • Source:
    Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2006 May; Vol. 6 (5), pp. 533-42.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101094212 Publication Model: Print Cited Medium: Print ISSN: 1389-5575 (Print) Linking ISSN: 13895575 NLM ISO Abbreviation: Mini Rev Med Chem Subsets: MEDLINE
    • Publication Information:
      Original Publication: Hilversum, The Netherlands; Boca Raton, FL : Bentham Science Publishers, c2001-
    • Subject Terms:
      Antineoplastic Agents/*pharmacology ; Lipids/*pharmacology; Antineoplastic Agents/chemistry ; Cations ; Lipids/chemistry ; Molecular Structure ; Phosphorus/chemistry ; Structure-Activity Relationship
    • Abstract:
      This review focuses on the synthesis and mechanisms of antitumor activity of cationic non-phosphorus analogs of edelfosine. The role of variable length and mode of conjugation of the spacer group, the types of cationic 'head', and the length of the substituent at C2 atom of the glycerol backbone are discussed, providing the basis for rational design of lipophilic anticancer drugs, in particular, for elimination of multidrug resistant cells.
    • Number of References:
      58
    • Accession Number:
      0 (Antineoplastic Agents)
      0 (Cations)
      0 (Lipids)
      27YLU75U4W (Phosphorus)
    • Publication Date:
      Date Created: 20060525 Date Completed: 20060801 Latest Revision: 20190917
    • Publication Date:
      20240829
    • Accession Number:
      10.2174/138955706776876221
    • Accession Number:
      16719826