Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential.

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  • Author(s): Shu Y;Shu Y; Hasenstaub A; Duque A; Yu Y; McCormick DA
  • Source:
    Nature [Nature] 2006 Jun 08; Vol. 441 (7094), pp. 761-5. Date of Electronic Publication: 2006 Apr 12.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
    • Publication Information:
      Publication: Basingstoke : Nature Publishing Group
      Original Publication: London, Macmillan Journals ltd.
    • Subject Terms:
      Cerebral Cortex/*cytology ; Cerebral Cortex/*physiology ; Membrane Potentials/*physiology ; Neurons/*physiology ; Synapses/*physiology; Action Potentials/physiology ; Animals ; Axons/physiology ; Dendrites/physiology ; Excitatory Postsynaptic Potentials/physiology ; Ferrets/physiology ; Neurons/cytology ; Presynaptic Terminals/physiology ; Pyramidal Cells/cytology ; Pyramidal Cells/physiology ; Synaptic Transmission
    • Abstract:
      Traditionally, neuronal operations in the cerebral cortex have been viewed as occurring through the interaction of synaptic potentials in the dendrite and soma, followed by the initiation of an action potential, typically in the axon. Propagation of this action potential to the synaptic terminals is widely believed to be the only form of rapid communication of information between the soma and axonal synapses, and hence to postsynaptic neurons. Here we show that the voltage fluctuations associated with dendrosomatic synaptic activity propagate significant distances along the axon, and that modest changes in the somatic membrane potential of the presynaptic neuron modulate the amplitude and duration of axonal action potentials and, through a Ca2+-dependent mechanism, the average amplitude of the postsynaptic potential evoked by these spikes. These results indicate that synaptic activity in the dendrite and soma controls not only the pattern of action potentials generated, but also the amplitude of the synaptic potentials that these action potentials initiate in local cortical circuits, resulting in synaptic transmission that is a mixture of triggered and graded (analogue) signals.
    • Comments:
      Comment in: Nature. 2006 Jun 8;441(7094):702-3. (PMID: 16760964)
    • Publication Date:
      Date Created: 20060421 Date Completed: 20060713 Latest Revision: 20220309
    • Publication Date:
      20231215
    • Accession Number:
      10.1038/nature04720
    • Accession Number:
      16625207