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Isolated nonsyndromic cleft palate: multicenter epidemiological study in the Brazil.
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- Author(s): Trezena, Samuel; Machado, Renato Assis; de Almeida Reis, Silvia Regina; Scariot, Rafaela; Rangel, Ana Lúcia Carrinho Ayroza; de Oliveira, Fabrício Emanuel Soares; Borges, Anna Júlia; Silva, Alissa Tamara; Martelli, Daniella R. Barbosa; Martelli Júnior, Hercílio
- Source:
BMC Oral Health; 7/14/2023, Vol. 23 Issue 1, p1-6, 6p- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: Background: Nonsyndromic orofacial clefts (NSOC) are the craniofacial most common congenital malformations. There are evidences that the nonsyndromic cleft palate (NSCP) development differs from other NSOC. However, most of the publications treat NSCP without considering that information. Furthermore, few studies focus on NSCP. The aim of this study was to describe epidemiological findings of patients with isolated NSCP in Brazil. Methods: In this cross-sectional multicenter study, four reference Centers for treatment in three different Brazilian states was investigated. Data were obtained from clinical records of patients, between November 2021 and June 2022. Researched variables were sociodemographic, clinical characteristics and pregnancy and family history. Pearson's chi-square and ANOVA One-way tests were used for associations. Results: Majority were female (58.1%), white (60.7%) with incomplete NSCP (61.2%). There was an association between complete NSCP and a positive history of medical problems during pregnancy (p = 0.016; 27.9%; OR: 1.94; 1.12–3.35). Systemic alterations were perceived in 40.6% of the sample with odds ratio for development of the complete type (OR: 1.21; 0.74–1.97). Higher OR was visualized in medication use during pregnancy (OR: 1.35; 0.76–2.37) and positive family history of oral cleft (OR: 1.44; 0.80–2.55). Dental and surgical care was associated with higher age groups (p < 0.050). Conclusions: NSCP was most prevalent in white skin color female. Complete NSCP is associated with medical problems during pregnancy. Medication use during pregnancy and positive family history of oral cleft increase the chance of developing complete NSCP. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of BMC Oral Health is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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