Epidermolysis Bullosa: Management Principles for the Neonate, Infant, and Young Child.

EPIDERMOLYSIS bullosa; EPITHELIUM; MUCOUS membranes; SKIN diseases; KERATINOCYTES; NEWBORN infants

This article presents information on epidermolysis bullosa (EB). EB is the term given to a group of inherited mechanobullous disorders involving blistering of the skin and sometimes mucous membranes in response to minor frictional trauma. In all forms of EB simplex (EBS), blisters form by cytolysis of the infranuclear portion of the basal keratinocytes. EBS Dowling-Meara is a form of the disease with neonatal widespread blistering progressing to blistering in characteristic clusters. EBS is inherited in an autosomal dominant manner with a few exceptions.