The amphibian globin gene repertoire as revealed by the Xenopus genome.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Fuchs C;Fuchs C; Burmester T; Hankeln T
  • Source:
    Cytogenetic and genome research [Cytogenet Genome Res] 2006; Vol. 112 (3-4), pp. 296-306.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: S. Karger Country of Publication: Switzerland NLM ID: 101142708 Publication Model: Print Cited Medium: Internet ISSN: 1424-859X (Electronic) Linking ISSN: 14248581 NLM ISO Abbreviation: Cytogenet Genome Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel ; New York : S. Karger, c2002-
    • Subject Terms:
      Chromosome Mapping*; Globins/*genetics ; Xenopus/*genetics; Algorithms ; Amino Acid Sequence ; Animals ; Base Sequence ; Cloning, Molecular ; DNA Primers ; DNA, Complementary/genetics ; Databases, Nucleic Acid ; Genome ; Molecular Sequence Data ; Sequence Alignment ; Sequence Homology, Amino Acid ; Xenopus laevis/genetics
    • Abstract:
      The draft genome sequence of the Western clawed frog Xenopus (Silurana) tropicalis facilitates the identification, expression analysis and phylogenetic classification of the amphibian globin gene repertoire. Frog and mammalian neuroglobin display about 67% protein sequence identity, with the expected predominant expression in frog brain and eye. Frog and mammalian cytoglobins share about 69% of their amino acids, but the frog protein lacks the mammalian-type extension at the C-terminus. Like in mammals, X. tropicalis cytoglobin is expressed in many organs including neural tissue. Neuroglobin and cytoglobin genomic regions are syntenically conserved in all vertebrate classes. Frog and fish globin X show only 57% amino acid identity, but gene synteny analysis confirms orthology. The expression pattern of X. laevis globin X differs from that in fish, with a prominent expression in the eye and weak expression in most other examined tissues. Globin X is possibly present as two paralogous copies in X. tropicalis, with one copy showing transition stages of non-functionalization. The amphibian genome contains a previously unknown globin type (tentatively named 'globin Y') which is expressed in a broad range of tissues and is distantly related to the cytoglobin lineage. The globin Y gene is linked to a cluster of larval and adult hemoglobin alpha and beta genes which contains substantially more paralogous hemoglobin gene copies than previously published. Database and gene synteny analyses confirm the absence of a myoglobin gene in X. tropicalis.
      (2006 S. Karger AG, Basel.)
    • Accession Number:
      0 (DNA Primers)
      0 (DNA, Complementary)
      9004-22-2 (Globins)
    • Publication Date:
      Date Created: 20060218 Date Completed: 20060313 Latest Revision: 20061115
    • Publication Date:
      20221213
    • Accession Number:
      10.1159/000089884
    • Accession Number:
      16484786