Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry.

PUBLIC health surveillance; MATERNAL health services; EVALUATION of medical care; COVID-19; COMMUNICABLE diseases; NEONATAL intensive care; PREMATURE infants; COVID-19 vaccines; PREGNANT women; NEONATAL intensive care units; DISEASE incidence; COMPARATIVE studies; HOSPITAL mortality; PREGNANCY complications; PUERPERIUM; DESCRIPTIVE statistics; SYMPTOMS; RESEARCH funding; COVID-19 testing; POLYMERASE chain reaction; COVID-19 pandemic; VERTICAL transmission (Communicable diseases); PERINATAL period; CHILDREN

OBJECTIVES: The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology Of Perinatal coronavirus disease 2019(COVID-19) (NPC-19) was developed to provide information on the Effects of perinatal severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) infection. METHODS: National Registry for the Surveillance and Epidemiology of Perinatal COVID-19 participating centers entered maternal and newborn data for pregnant persons who tested positive for SARS-CoV-2 infection between 14 days before and 10 days after delivery. Incidence of and morbidities associated with maternal and newborn SARS-CoV-2 infection were assessed. RESULTS: From April 6, 2020 to March 19, 2021, 242 centers in the United States centers reported data for 7524 pregnant persons; at the time of delivery, 78.1%of these persons were asymptomatic, 18.2% were symptomatic but not hospitalized specifically for COVID-19, 3.4%were hospitalized for COVID-19 treatment, and 18 (0.2%) died in the hospital of COVID-related complications. Among 7648 newborns, 6486 (84.8%) were tested for SARS-CoV-2, and 144 (2.2%) were positive; the highest rate of newborn infection was observed when mothers first tested positive in the immediate postpartum period (17 of 125, 13.6%). No newborn deaths were attributable to SARS-CoV-2 infection. Overall, 15.6% of newborns were preterm: among tested newborns, 30.1%of polymerase chain reaction positive and 16.2%of polymerase chain reaction-negative were born preterm (P< .001). Need for mechanical ventilation did not differ by newborn SARS-CoV-2 test result, but those with positive tests were more likely to be admitted to a NICU. CONCLUSIONS: Early in the pandemic, SARS-CoV-2 infection was acquired by newborns at variable rates And without apparent short-term effects. During a period that preceded widespread availability of vaccines, we observed higher than expected numbers of preterm births and maternal in-hospital deaths. [ABSTRACT FROM AUTHOR]

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