Is amyotrophic lateral sclerosis a prion-like disorder? A case report.

Notably, in these diseases, TDP-43 pathology in muscles does not propagate via peripheral nerves to the spinal cord and develop ALS pathology [[7]]. TDP-43 pathology was found equally and frequently not only in upper motor neurons but also lower motor neurons bilaterally, despite almost complete disconnection of the right pyramidal tract at the internal capsule level due to a cerebral infarct that occurred 10 years before ALS onset. However, several staging schemes for TDP-43 in ALS indicate that TDP-43 pathology may spread independent loss of upper and lower motor neurons [[2]]. [Extracted from the article]

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