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West Ashley Library
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Phone: (843) 766-6635
Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
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Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
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McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
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Hurd/St. Andrews Library
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Analgesic utilization in people with knee osteoarthritis: A population‐based study using primary care data.
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- Author(s): Taqi, Aqila; Gran, Sonia; Knaggs, Roger D.
- Source:
Pain Practice. Jun2023, Vol. 23 Issue 5, p523-534. 12p. 2 Charts, 6 Graphs. - Source:
- Additional Information
- Subject Terms: KNEE osteoarthritis; CHRONIC pain; ANTIDEPRESSANTS; PAIN; ANALGESICS; CROSS-sectional method; ACETAMINOPHEN; NONSTEROIDAL anti-inflammatory agents; PRIMARY health care; MORPHINE; DESCRIPTIVE statistics; RESEARCH funding; OPIOID analgesics; MEDICAL prescriptions; EPIDEMIOLOGICAL research; OFF-label use (Drugs)
- Subject Terms:
- Abstract: Purpose: Osteoarthritis (OA) is a chronic painful condition that often affects large joints such as the knee. Treatment guidelines recommend paracetamol, nonsteroidal anti‐inflammatory drugs (NSAIDs), and opioids. Antidepressants and anti‐epileptic drugs (AEDs) are commonly prescribed for chronic noncancer pain conditions including OA, as an off‐label use. This study describes analgesic utilization in patients with knee OA at population level using standard pharmaco‐epidemiological methods. Method: This was a cross‐sectional study between 2000 and 2014 using data from the U.K. Clinical Practice Research Datalink (CPRD). The use of antidepressants, AEDs, opioids, NSAIDs, and paracetamol was studied in adults with knee OA using the following measures: annual number of prescriptions, defined daily doses (DDD), oral morphine equivalent dose (OMEQ), and days' supply. Results: In total, there were 8,944,381 prescriptions prescribed for 117,637 patients with knee OA during the 15‐year period. There was a steady increase in the prescribing of all drug classes, except for NSAIDs, over the study period. Opioids were the most prevalent class prescribed in every study year. Tramadol was the most commonly prescribed opioid, with the number of DDD increasing from 0.11 to 0.71 DDDs per 1000 registrants in 2000 and 2014, respectively. The largest increase in prescribing was for AEDs, where the number of prescriptions increased from 2 to 11 per 1000 CPRD registrants. Conclusion: There was an overall increase in the prescribing of analgesics apart from NSAIDs. Opioids were the most frequently prescribed class; however, the greatest increase in prescribing between 2000 and 2014 was observed in AEDs. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Pain Practice is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Subject Terms:
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