Randomized clinical trial of the effect of preoperative dexamethasone on nausea and vomiting after laparoscopic cholecystectomy.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 0372553 Publication Model: Print Cited Medium: Print ISSN: 0007-1323 (Print) Linking ISSN: 00071323 NLM ISO Abbreviation: Br J Surg Subsets: MEDLINE
    • Publication Information:
      Publication: 2021- : [Oxford] : Oxford University Press
      Original Publication: [Bristol, England : Baltimore : John Wright & Sons ; Williams & Wilkins Co.
    • Subject Terms:
      Antiemetics/*therapeutic use ; Cholecystectomy, Laparoscopic/*adverse effects ; Dexamethasone/*therapeutic use ; Gallbladder Diseases/*surgery ; Postoperative Nausea and Vomiting/*prevention & control; Analgesics/therapeutic use ; Double-Blind Method ; Female ; Humans ; Length of Stay ; Male ; Middle Aged ; Pain Measurement ; Pain, Postoperative/prevention & control ; Patient Satisfaction ; Treatment Outcome
    • Abstract:
      Background: Preoperative dexamethasone may reduce disabling symptoms such as pain, nausea and vomiting after laparoscopic cholecystectomy.
      Methods: This was a randomized, double-blind, placebo-controlled trial. Between March and December 2004, 101 patients undergoing laparoscopic cholecystectomy were randomized to receive 8 mg dexamethasone (n = 49) or placebo (n = 52) intravenously before surgery. Six patients were excluded from the study. All patients received a standardized anaesthetic, surgical and multimodal analgesic treatment. The primary endpoints were: first, postoperative nausea, vomiting and pain; second, postoperative analgesic and antiemetic requirements. The pain scores (visual analogue and verbal response scales), the episodes of nausea (verbal response scale) and vomiting were recorded at 1, 3, 6 and 24 h, respectively, after the operation. Analgesic and antiemetic requirements were also recorded.
      Results: No apparent drug side-effects were noted. Seven patients (14 per cent) in the treatment group reported nausea and vomiting compared with 24 (46 per cent) in the control group (P = 0.001). In the group of patients treated with dexamethasone, five (10 per cent) required antiemetics versus 23 (44 per cent) of those receiving placebo (P < 0.001). No difference in postoperative pain scores and analgesic requirements was detected between groups.
      Conclusion: Preoperative dexamethasone reduces postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy, with no side-effects, and may be recommended for routine use.
      (Copyright (c) 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.)
    • Accession Number:
      0 (Analgesics)
      0 (Antiemetics)
      7S5I7G3JQL (Dexamethasone)
    • Publication Date:
      Date Created: 20060110 Date Completed: 20060413 Latest Revision: 20220408
    • Publication Date:
      20240829
    • Accession Number:
      10.1002/bjs.5252
    • Accession Number:
      16400707