Brief Report: The Characterization of Medical Comorbidity Prior to Autism Diagnosis in Children Before Age Two.

DIAGNOSIS of autism; BIOMARKERS; EPILEPSY; DEVELOPMENTAL disabilities; RISK assessment; NYSTAGMUS; ELECTRONIC health records; LOGISTIC regression analysis; COMORBIDITY; EARLY diagnosis; STRABISMUS; JAUNDICE; CHILDREN

In autism spectrum disorder (ASD), medical conditions in infancy could be predictive markers for later ASD diagnosis. In this study, electronic medical records of 579 autistic individuals and 1897 matched controls prior to age 2 were analyzed for potential predictive conditions. Using a novel tool, the relative association of each condition in the autistic group was compared to the control group using logistic regressions across medical records. Generalized convulsive epilepsy, nystagmus, lack of normal physiological development, delayed milestones, and strabismus were more likely in those later diagnosed with ASD while perinatal jaundice was less likely to be associated. Lesser-known conditions, such as strabismus and nystagmus, may point to novel predictive co-occurring condition profiles which could improve screening practices for ASD. [ABSTRACT FROM AUTHOR]