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Phone: (843) 766-6635
Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
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Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma.
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- Author(s): Asada, Hajime; Tani, Akiyoshi; Sakuma, Hiroki; Hirabayashi, Miyuki; Matsumoto, Yuki; Watanabe, Kei; Tsuboi, Masaya; Yoshida, Shino; Harada, Kei; Uchikai, Takao; Goto-Koshino, Yuko; Chambers, James K.; Ishihara, Genki; Kobayashi, Tetsuya; Irie, Mitsuhiro; Uchida, Kazuyuki; Ohno, Koichi; Bonkobara, Makoto; Tsujimoto, Hajime; Tomiyasu, Hirotaka
- Source:
Scientific Reports; 5/25/2023, Vol. 13 Issue 1, p1-12, 12p- Subject Terms:
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- Additional Information
- Abstract: Histiocytic sarcoma (HS) is an incurable aggressive tumor, and no consensus has been made on the treatment due to its rare occurrence. Since dogs spontaneously develop the disease and several cell lines are available, they have been advocated as translational animal models. In the present study, therefore, we explored gene mutations and aberrant molecular pathways in canine HS by next generation sequencing to identify molecular targets for treatment. Whole exome sequencing and RNA-sequencing revealed gene mutations related to receptor tyrosine kinase pathways and activation of ERK1/2, PI3K-AKT, and STAT3 pathways. Analysis by quantitative PCR and immunohistochemistry revealed that fibroblast growth factor receptor 1 (FGFR1) is over-expressed. Moreover, activation of ERK and Akt signaling were confirmed in all HS cell lines, and FGFR1 inhibitors showed dose-dependent growth inhibitory effects in two of the twelve canine HS cell lines. The findings obtained in the present study indicated that ERK and Akt signaling were activated in canine HS and drugs targeting FGFR1 might be effective in part of the cases. The present study provides translational evidence that leads to establishment of novel therapeutic strategies targeting ERK and Akt signaling in HS patients. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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