[A case-control study on the mxA polymorphisms and susceptibility to severe acute respiratory syndromes].

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  • Additional Information
    • Source:
      Publisher: Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo Country of Publication: China NLM ID: 8208604 Publication Model: Print Cited Medium: Print ISSN: 0254-6450 (Print) Linking ISSN: 02546450 NLM ISO Abbreviation: Zhonghua Liu Xing Bing Xue Za Zhi Subsets: MEDLINE
    • Publication Information:
      Publication: Beijing : Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo
      Original Publication: [Beijing] : Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo, [1981-
    • Subject Terms:
      Genetic Predisposition to Disease* ; Polymorphism, Genetic*; GTP-Binding Proteins/*genetics ; Severe Acute Respiratory Syndrome/*genetics; Adult ; Case-Control Studies ; Female ; Humans ; Logistic Models ; Male ; Multivariate Analysis ; Myxovirus Resistance Proteins
    • Abstract:
      Objective: To investigate the association between the genetic polymorphisms of myxovirus resistance 1 (MxA) gene and susceptibility to severe acute respiratory syndromes (SARS).
      Methods: A case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the T/G polymorphism at position-88 in the mxA gene promoter. Information on related factors of SARS was collected using a pre-testing questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package.
      Results: Sixty-six cases and sixty-four controls were selected for the study. Comparing with GG genotype, the proportion of GT genotype were significantly higher in the case group (81.3%) than that in the control group (62.5%)) with an OR (95% CI) of 2.700 (1.208-6.037). Multivariate logistic regression analysis revealed that the significant association remained after factors as wearing masks, protection gowns and eye-protection when contacting with SARS patient etc. were adjusted with an OR (95 % CI) of 2.911 (1.027-8.250).
      Conclusion: mxA promoter-88G/T SNP might be confered to host genetic susceptibility to SARS in Chinese Han population.
    • Accession Number:
      0 (MX1 protein, human)
      0 (Myxovirus Resistance Proteins)
      EC 3.6.1.- (GTP-Binding Proteins)
    • Publication Date:
      Date Created: 20060105 Date Completed: 20100519 Latest Revision: 20131121
    • Publication Date:
      20240829
    • Accession Number:
      16390004