[New kinds of AIDS drugs inhibit HIV entry into the cell. Entry inhibitors soon for oral administration].

Neuartige AIDS-medikamente verwehren HI-Viren den Eintritt in die Zelle. Entry-Inhibitoren demnächst auch oral.

Publisher: Springer Country of Publication: Germany NLM ID: 100893959 Publication Model: Print Cited Medium: Print ISSN: 1438-3276 (Print) Linking ISSN: 14383276 NLM ISO Abbreviation: MMW Fortschr Med Subsets: MEDLINE

Publication: 2012- : Berlin : Springer
Original Publication: München : Urban & Vogel, [1999-

CCR5 Receptor Antagonists*; Anti-HIV Agents/*therapeutic use ; HIV Fusion Inhibitors/*therapeutic use ; HIV Infections/*drug therapy ; HIV-1/*drug effects ; Receptors, Chemokine/*antagonists & inhibitors ; Receptors, Virus/*antagonists & inhibitors ; Virus Integration/*drug effects; Administration, Oral ; Anti-HIV Agents/adverse effects ; Drug Resistance, Viral ; HIV Fusion Inhibitors/adverse effects ; HIV Infections/virology ; Humans ; Randomized Controlled Trials as Topic ; Receptors, CCR4 ; Retreatment ; Virus Inactivation/drug effects

Entry inhibitors include a variety of drugs with different points of attack and with the common objective of preventing the entry of HIV into the cell. Whereas the only previously approved medication from this group, enfuvirtide, can be only injected subcutaneously and, thus, is indicated for only treatment-experienced patients, the CCR5 antagonists represent a group of experimental medications whose use is conceivable at all stages of the HIV infection. According to the available data, they are effective and also very well tolerated and, therefore, are one of the most promising future classes of drugs. At the moment, the prospective importance of substances possessing other mechanisms of action (attachment inhibitors, CXCR4 inhibitors) can not yet be predicted.

0 (Anti-HIV Agents)
0 (CCR4 protein, human)
0 (CCR5 Receptor Antagonists)
0 (HIV Fusion Inhibitors)
0 (Receptors, CCR4)
0 (Receptors, Chemokine)
0 (Receptors, Virus)

Date Created: 20060103 Date Completed: 20060227 Latest Revision: 20141120

20240829

16385874