Long-term Mortality of a Cohort of Patients Undergoing Surgical Treatment for Diabetic Foot Infections. An 8-year Follow-up Study.

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  • Additional Information
    • Subject Terms:
      MORTALITY risk factors; INSULIN therapy; GLOMERULAR filtration rate; CONFIDENCE intervals; DIABETIC foot; WOUND infections; OPERATIVE surgery; RETROSPECTIVE studies; SURGERY; PATIENTS; PATIENT readmissions; REINFECTION; TREATMENT effectiveness; RISK assessment; DISEASE relapse; SEX distribution; KAPLAN-Meier estimator; DESCRIPTIVE statistics; LEG amputation; LONGITUDINAL method; PROPORTIONAL hazards models; EVALUATION
    • Subject Terms:
      COSTA Rica
    • Abstract:
      We analyzed a retrospective cohort of 150 patients with diabetic foot infections (DFIs) who underwent surgical treatment to determine long-term outcomes. The median follow-up of the series was 7.6 years. Cox's proportional hazards model for survival time was performed and hazard ratios (HRs) were estimated. Survival times were plotted using the Kaplan–Meier method. Fifteen patients (10%) required readmission after discharge from the hospital for a recurrence of the infection. Ninety patients (60%) had re-ulcerations. Forty-nine (54.4% of those re-ulcerated) required new admission and 24 of them (26.6% of those re-ulcerated) finally required a new amputation. Overall cumulative survival rates at 1, 5, and 8 years were 95%, 78%, and 64%, respectively. Predictive variables of long-term mortality were insulin treatment (HR: 2.0, 95% CI: 1.1-3.6, P =.01), female sex (HR: 3.1, 95% CI: 1.7-5.3, P <.01) and estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 (HR: 2.2, 95% CI: 1.1-4.2, P =.01). In conclusion, patients undergoing surgical treatment for DFIs had a high rate of recurrences and mortality. Women, patients who underwent treatment with insulin, and those with eGFR <60 ml/min/1.73 m2 had a higher risk of long-term mortality. [ABSTRACT FROM AUTHOR]
    • Abstract:
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