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Pretreatment Depressive Status Associated with Poor Nutrition and Prognosis in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.
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- Author(s): Xiao, Xiaodan; Huang, Siyin; Gan, Chengju; Quan, Xiaoli; Xiang, Yali; Zheng, Baojia
- Source:
Nutrition & Cancer. 2023, Vol. 75 Issue 4, p1223-1232. 10p. 3 Charts, 3 Graphs. - Source:
- Additional Information
- Subject Terms: BREAST tumor treatment; BLOOD sugar analysis; PROTEIN analysis; FASTING; CONFIDENCE intervals; CANCER chemotherapy; SODIUM; MULTIVARIATE analysis; IDENTIFICATION; POTASSIUM; PATIENTS; CANCER patients; NEUTROPHIL lymphocyte ratio; RISK assessment; MENTAL depression; QUESTIONNAIRES; COMBINED modality therapy; PROGRESSION-free survival; BODY mass index; NUTRITIONAL status; CHOLESTEROL; PROPORTIONAL hazards models
- Abstract: The prevalence of pretreatment depression in breast cancer patients and its impact on nutrition and prognosis during neoadjuvant chemotherapy remain unknown. One hundred twenty-one patients with previously untreated breast cancer undergoing neoadjuvant chemotherapy (NAC) were enrolled. Patients completed the Self-rating Depressive symptoms Scale (SDS) before treatment and were divided into two groups (non-depressive group and depressive group). The nutrition risk screening-2002 (NRS-2002), and nutritional and prognostic indicators, including neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI), were collected at baseline (pretreatment) and post-treatment. One- and two-year progression-free survival (PFS) in both groups were also calculated. We found that 38.84% patients experienced pretreatment depressive symptoms. Patients in the depressive group had higher nutritional risk and lower body mass index, potassium, sodium, total cholesterol, total protein, and fasting blood glucose levels than those in pretreatment non-depressive group after NAC (all p < 0.05). And higher NLR (p = 0.039) and lower PNI level (p = 0.0021) after NAC were found in patients with pretreatment depressive status. Multivariable Cox analysis showed pretreatment depressive status (HR: 1.893; 95% CI: 1.047-3.426; p = 0.034) were a significant predictor of PFS. This study provides evidence for early identification of pretreatment depression in patients receiving NAC, which would certainly favor nutrition and survival outcome. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Nutrition & Cancer is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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