Is the platelet serotonin transporter different in venous vs. arterial blood?

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  • Additional Information
    • Source:
      Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Print Cited Medium: Print ISSN: 0364-3190 (Print) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers
      Original Publication: New York, Plenum Press
    • Subject Terms:
      Arteries/*metabolism ; Blood/*metabolism ; Serotonin Plasma Membrane Transport Proteins/*blood ; Veins/*metabolism; Animals ; Blood Platelets/metabolism ; Female ; Humans ; Male ; Paroxetine/metabolism ; Protein Processing, Post-Translational ; Quipazine/analogs & derivatives ; Quipazine/metabolism ; Rats ; Rats, Wistar ; Serotonin Plasma Membrane Transport Proteins/genetics ; Serotonin Receptor Agonists/chemistry ; Serotonin Receptor Agonists/metabolism ; Selective Serotonin Reuptake Inhibitors/metabolism
    • Abstract:
      The binding of labelled paroxetine to the serotonin transporter (SERT) of platelet membranes has been studied in both venous and mixed venous/arterial blood of the rat. In addition, we studied the inhibition of paroxetine binding to SERT by quipazine and N-methyl-quipazine (NMQ). The results indicate differences in affinity for the two test drugs, quipazine and NMQ, in venous vs. mixed venous/arterial blood. This suggests different post-translational modifications of SERT in platelets of arterial vs. venous blood.
    • References:
      Curr Top Med Chem. 2002 Jun;2(6):599-624. (PMID: 12052196)
      Bioorg Med Chem. 2005 May 16;13(10):3455-60. (PMID: 15848758)
      Am J Psychiatry. 1994 Nov;151(11):1623-5. (PMID: 7943450)
      J Biol Chem. 1948 Dec;176(3):1243-51. (PMID: 18100415)
      Arch Gen Psychiatry. 1981 Dec;38(12):1315-7. (PMID: 7316676)
      Experientia. 1988 Feb 15;44(2):115-26. (PMID: 2831073)
      Mol Pharmacol. 2005 Jun;67(6):2077-87. (PMID: 15774771)
      Clin Chim Acta. 2005 Jun;356(1-2):76-94. (PMID: 15936305)
      Ann N Y Acad Sci. 1990;600:282-95; discussion 295-6. (PMID: 2252316)
      J Neurochem. 1993 Jun;60(6):2319-22. (PMID: 7684072)
      Nature. 2002 Jan 10;415(6868):175-9. (PMID: 11805836)
      J Biol Chem. 2005 Apr 22;280(16):15649-58. (PMID: 15728187)
      J Biol Chem. 2003 Nov 7;278(45):43991-4000. (PMID: 12944413)
      Br J Haematol. 2003 Jun;121(6):892-6. (PMID: 12786800)
      J Biol Chem. 1998 Jan 23;273(4):2458-66. (PMID: 9442097)
    • Accession Number:
      0 (Serotonin Plasma Membrane Transport Proteins)
      0 (Serotonin Receptor Agonists)
      0 (Serotonin Uptake Inhibitors)
      41VRH5220H (Paroxetine)
      4WCY05C0SJ (Quipazine)
    • Publication Date:
      Date Created: 20051213 Date Completed: 20060215 Latest Revision: 20221207
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/s11064-005-8342-x
    • Accession Number:
      16341932