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9 a.m. - 7 p.m.
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Wando Mount Pleasant Library
9 a.m. - 8 p.m.
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Village Library
9 a.m. - 6 p.m.
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St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
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Otranto Road Library
9 a.m. - 8 p.m.
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Mt. Pleasant Library
9 a.m. - 8 p.m.
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McClellanville Library
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Keith Summey North Charleston Library
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Hurd/St. Andrews Library
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Folly Beach Library
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Dorchester Road Library
9 a.m. - 8 p.m.
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John L. Dart Library
9 a.m. - 7 p.m.
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Bees Ferry West Ashley Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Changes in Medication Use During Pregnancy for Women with Chronic Conditions: An Analysis of Claims Data.
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- Author(s): Hernandez, Rohini K.1 (AUTHOR) ; Nakasian, Sonja S.2 (AUTHOR); Bollinger, Lisa3 (AUTHOR); Bradbury, Brian D.1 (AUTHOR); Jick, Susan S.4 (AUTHOR); Muntner, Paul5 (AUTHOR); Ng, Eric3 (AUTHOR); Chia, Victoria1 (AUTHOR)
- Source:
Therapeutic Innovation & Regulatory Science. May2023, Vol. 57 Issue 3, p570-579. 10p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Purpose: Evaluation of drug safety during pregnancy is dependent on the number of exposed women during routine clinical practice with data available for analysis. We examined medication fills in pregnant and nonpregnant women within select disease cohorts: general population, migraine, diabetes, and hyperlipidemia to explore the potential use of claims data to assess medication use and safety during pregnancy. Methods: This cohort study, using IBM MarketScan® Research Databases claims data, included women 10–54 years of age with pregnancy resulting in a liveborn infant between January 2010 and September 2015 and matched nonpregnant women. Medication use (antidepressants, antihypertensives, sedatives, glucose-lowering medications, antiepileptics, antipsychotics, lipid-lowering medications) was abstracted from pharmacy claims 180 days before last menstrual period through 180 days postdelivery. Results: Among 753,760 women in the general pregnancy population (including 73,268 migraine, 50,155 hyperlipidemia, and 8361 diabetes; non-exclusive cohorts), antidepressants, antihypertensives, and sedatives were the most commonly used medications during pregnancy. Medications of interest were less commonly used in the pregnancy cohort than in the matched nonpregnant cohort within each time period (e.g., 3.7% vs 13.1% antidepressant use in 1st trimester). Most prescription fills were less common during pregnancy then pre-pregnancy. Post-pregnancy, prescription fills increased to or exceeded pre-pregnancy levels, except antihypertensive and glucose-lowering medications, which increased during pregnancy. Conclusions: Medication use among pregnant women was low and different from that among matched nonpregnant women. The underlying size of large commercial claims databases offer opportunities for efficient evaluation of potential safety concerns, particularly for rare drug exposures, compared to traditional pregnancy registries. [ABSTRACT FROM AUTHOR]
- Abstract:
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