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Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood.
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- Author(s): Michael, Navin1 (AUTHOR) ; Gupta, Varsha1 (AUTHOR); Fogel, Anna1 (AUTHOR); Huang, Jonathan1 (AUTHOR); Chen, Li1 (AUTHOR); Sadananthan, Suresh Anand1 (AUTHOR); Ong, Yi Ying2 (AUTHOR); Aris, Izzuddin M3 (AUTHOR); Pang, Wei Wei4 (AUTHOR); Yuan, Wen Lun1,5 (AUTHOR); Loy, See Ling1,6,7 (AUTHOR); Tint, Mya Thway1,4 (AUTHOR); Tan, Kok Hian8,9 (AUTHOR); Chan, Jerry Ky6,7 (AUTHOR); Chan, Shiao-Yng1,4 (AUTHOR); Shek, Lynette Pei-Chi1,2 (AUTHOR); Yap, Fabian7,10,11 (AUTHOR); Godfrey, Keith12 (AUTHOR); Chong, Yap Seng1,4 (AUTHOR); Gluckman, Peter1,13 (AUTHOR)
- Source:
International Journal of Epidemiology. Apr2023, Vol. 52 Issue 2, p426-439. 14p.- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: Background Longitudinal assessment of the determinants of obesogenic growth trajectories in childhood can suggest appropriate developmental windows for intervention. Methods Latent class growth mixture modelling was used to identify body mass index (BMI) z-score trajectories from birth to age 6 years in 994 children from a prospective mother–offspring cohort (Chinese, Indian and Malay ethnicities) based in Singapore. We evaluated the early-life determinants of the trajectories as well as their associations with cardiometabolic risk markers at age 6 years. Results Five BMI z-score trajectory patterns were identified, three within the healthy weight range, alongside early-acceleration and late-acceleration obesogenic trajectories. The early-acceleration pattern was characterized by elevated fetal abdominal circumference growth velocity, BMI acceleration immediately after birth and crossing of the obesity threshold by age 2 years. The late-acceleration pattern had normal fetal growth and BMI acceleration after infancy, and approached the obesity threshold by age 6 years. Abdominal fat, liver fat, insulin resistance and odds of pre-hypertension/hypertension were elevated in both groups. Indian ethnicity, high pre-pregnancy BMI, high polygenic risk scores for obesity and shorter breastfeeding duration were common risk factors for both groups. Malay ethnicity and low maternal educational attainment were uniquely associated with early BMI acceleration, whereas nulliparity and obesogenic eating behaviours in early childhood were uniquely associated with late BMI acceleration. Conclusion BMI acceleration starting immediately after birth or after infancy were both linked to early cardiometabolic alterations. The determinants of these trajectories may be useful for developing early risk stratification and intervention approaches to counteract metabolic adversities linked to childhood obesity. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of International Journal of Epidemiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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