[Light therapy of newborns with hyperbilirubinemia].

Lysbehandling av nyfødte med hyperbilirubinemi.

Publisher: Norske Laegeforening Country of Publication: Norway NLM ID: 0413423 Publication Model: Print Cited Medium: Print ISSN: 0029-2001 (Print) Linking ISSN: 00292001 NLM ISO Abbreviation: Tidsskr Nor Laegeforen Subsets: MEDLINE

Publication: Oslo : Norske Laegeforening
Original Publication: Chistiania : Alb. Cammermeyer, 1880-

Phototherapy*/adverse effects ; Phototherapy*/methods; Jaundice, Neonatal/*therapy; Bilirubin/chemistry ; Bilirubin/metabolism ; Humans ; Infant, Newborn

In a significant fraction of newborns the skin becomes yellow for a few days after birth due to accumulation of bilirubin, a product of heme catabolism. If the concentration of bilirubin in the serum approaches the binding capacity of albumin, bilirubin may penetrate into the central nervous system and cause irreversible damage. Phototherapy is the most common form of therapy, used on 5-10% of all newborns in Norway. Three photochemical reactions are of importance in this treatment: Photooxydation of bilirubin followed by fragmentation of the molecule and formation of water-soluble products. Reversible formation of (4Z,15E) and (less important) (4E,15Z) configurational isomers. Irreversible formation of the structure isomer Z-lumirubin, which is relatively water-soluble and can be excreted. The (4E,15Z) isomer is probably an intermediate in the formation of Z-lumirubin, whose formation therefore requires the absorption of two photons. Irreversible formation of Z-lumirubin, which has a quantum yield that increases with increasing wavelength of the light, is believed to be the most important reaction in phototherapy. All known side-effects of phototherapy are transient and not serious.

16

RFM9X3LJ49 (Bilirubin)

Date Created: 19920430 Date Completed: 19920819 Latest Revision: 20131121

20221208

1631823