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Wando Mount Pleasant Library
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Cytokine production by human B cells: role in health and autoimmune disease.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): de Gruijter, Nina M (AUTHOR); Jebson, Bethany (AUTHOR); Rosser, Elizabeth C (AUTHOR)
- Source:
Clinical & Experimental Immunology. Dec2022, Vol. 210 Issue 3, p253-262. 10p. 3 Diagrams. - Source:
- Additional Information
- Subject Terms:
- Abstract: B cells are classically considered solely as antibody-producing cells driving humoral immune responses to foreign antigens in infections and vaccinations as well as self-antigens in pathological settings such as autoimmunity. However, it has now become clear that B cells can also secrete a vast array of cytokines, which influence both pro- and anti-inflammatory immune responses. Indeed, similarly to T cells, there is significant heterogeneity in cytokine-driven responses by B cells, ranging from the production of pro-inflammatory effector cytokines such as IL-6, through to the release of immunosuppressive cytokines such as IL-10. In this review, focusing on human B cells, we summarize the key findings that have revealed that cytokine-producing B cell subsets have critical functions in healthy immune responses and contribute to the pathophysiology of autoimmune diseases. B cells are classically considered solely as antibody-producing cells driving humoral immune responses to foreign antigens in infections and vaccinations as well as self-antigens in pathological settings such as autoimmunity. However, it has now become clear that B cells can also secrete a vast array of cytokines, which influence both pro- and anti-inflammatory immune responses. In this review, focusing on human B cells, we summarise the key findings that have revealed that cytokine-producing B cell subsets have critical functions in healthy immune responses and contribute to the pathophysiology of autoimmune diseases. [ABSTRACT FROM AUTHOR]
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