[Photoisomers of bilirubin in the blood of neonates during phototherapy].

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  • Author(s): Hodr R;Hodr R; Knobloch E
  • Source:
    Ceskoslovenska pediatrie [Cesk Pediatr] 1992 Apr; Vol. 47 (4), pp. 197-200.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Czech
  • Additional Information
    • Transliterated Title:
      Fotoizoméry bilirubinu v krvi novorozenců pri fototerapii.
    • Source:
      Publisher: Prace Publishing Country of Publication: Czech Republic NLM ID: 0403576 Publication Model: Print Cited Medium: Print ISSN: 0069-2328 (Print) Linking ISSN: 00692328 NLM ISO Abbreviation: Cesk Pediatr Subsets: MEDLINE
    • Publication Information:
      Publication: Praha : Prace Publishing
      Original Publication: Praha, Avicenum, zdravotnické nakladatelství.
    • Subject Terms:
      Phototherapy*; Bilirubin/*analysis ; Jaundice, Neonatal/*blood; Bilirubin/radiation effects ; Humans ; Infant, Newborn ; Isomerism ; Jaundice, Neonatal/therapy
    • Abstract:
      In a group of mature neonates with hyperbilirubinaemia the authors investigated by chromatography, using the HPLC method, levels of bilirubin photoisomers before phototherapy, in the course of phototherapy and after its termination. The configuration isomer 4 Z, 15 E is detected in blood of all icteric neonates already before the onset of treatment in a mean concentration of 5.2 (s = 3.8) mumol/l, during phototherapy its mean concentration is 23.0 (s = 8.0) mumol/l. Photoisomers participate in non-conjugated bilirubinaemia on average by 10%: 92% are formed by isomer 4 Z, 15 E, 5% by isomer 4 E, 15 Z and 3% by the structural isomer lumirubin. On the day following discontinuation of treatment the mean photoisomer concentrations are significantly lower than during phototherapy and significantly higher than before its initiation.
    • Accession Number:
      RFM9X3LJ49 (Bilirubin)
    • Publication Date:
      Date Created: 19920401 Date Completed: 19920814 Latest Revision: 20131121
    • Publication Date:
      20231215
    • Accession Number:
      1628353