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West Ashley Library
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Patient-reported outcomes in capmatinib-treated patients with METex14-mutated advanced NSCLC: Results from the GEOMETRY mono-1 study.
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- Author(s): Wolf, Jürgen1 (AUTHOR) ; Garon, Edward B.2 (AUTHOR) ; Groen, Harry J.M.3 (AUTHOR) ; Tan, Daniel S.W.4 (AUTHOR) ; Gilloteau, Isabelle5 (AUTHOR) ; Le Mouhaer, Sylvie6 (AUTHOR) ; Hampe, Marcio5 (AUTHOR) ; Cai, Can5 (AUTHOR) ; Chassot-Agostinho, Andrea6 (AUTHOR) ; Reynolds, Maria7 (AUTHOR) ; Sherif, Bintu7 (AUTHOR) ; Heist, Rebecca S.8 (AUTHOR)
- Source:
European Journal of Cancer. Apr2023, Vol. 183, p98-108. 11p.- Subject Terms:
*LUNG cancer diagnosis; *THERAPEUTIC use of antineoplastic agents; *LUNG cancer; *INTERLEUKINS; *GENETIC mutation; *CONFIDENCE intervals; *TIME; *HEALTH outcome assessment; *ANTINEOPLASTIC agents; *WORLD health; *VISUAL analog scale; *LUNG tumors; *TUMOR classification; *MATHEMATICS; *TREATMENT effectiveness; *DYSPNEA; *QUALITY of life; *QUESTIONNAIRES; *COUGH - Source:
- Additional Information
- Abstract: Capmatinib, a MET inhibitor, showed substantial antitumour activity with manageable side effects in patients with MET exon 14 (MET ex14)-mutated advanced non-small cell lung cancer (aNSCLC) in the GEOMETRY mono-1 study. We report patient-reported outcomes (PROs) from this study. Enrolled treatment-naïve (1L) or pre-treated (2L+) patients with aNSCLC with a MET ex14-skipping mutation received 400 mg capmatinib twice daily during 21-day treatment cycles. PROs were collected at baseline and every six weeks thereafter using EORTC QLQ-C30 global health status/quality of life (GHS/QoL), QLQ-LC13 symptoms, and EQ-5D-5L visual analogue scale (VAS) questionnaires. As of 6 January 2020, 27/28 1L and 65/69 2L+ patients had completed PROs at baseline; compliance rates remained >70%. Cough improved early, with meaningful improvements (≥10-point change from baseline) observed throughout cycles (mean change from baseline [SD] by week 7: 1L −13.0 [39.9], 2L+ −8.2 [28.4]; week 43: 1L −28.2 [26.7], 2L+ −10.5 [27.3]). QoL, assessed by GHS/QoL and VAS, improved by week 7 in 1L and 2L+ patients, with improvements generally sustained over time. Median time to definitive deterioration (TTDD) in GHS/QoL was 16.6 months (95% CI: 9.7, not estimable [NE]) in 1L and 12.4 months (95% CI: 4.2, 19.4) in 2L+ patients. Median TTDD for dyspnoea was 19.4 months (95% CI: 12.4, NE) and 22.1 months (95% CI: 9.9, NE) for 1L and 2L+ patients, respectively, and NE for cough and chest pain. Capmatinib was associated with clinically meaningful improvements in cough and preserved QoL, further supporting its use in patients with MET ex14-mutated aNSCLC. ClinicalTrials.gov registry number: NCT02414139. • Capmatinib is indicated for advanced NSCLC with MET exon 14 skipping alterations. • We present the analysis of the patient-reported outcomes from the GEOMETRY mono-1 trial. • Patient-reported outcomes included the EORTC QLQ-C30, EORTC QLQ-LC13, and EQ-5D-5L. • Capmatinib led to clinically meaningful improvements in cough and preserved QoL. • Benefit was observed for both treatment-naïve and previously treated patients. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Journal of Cancer is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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