Analysis of factors associated with hematopoietic stem-cell retransplantation: a case-control study.

CELL transplantation; RESEARCH; STATISTICS; CAUSES of death; DISEASE progression; MYELODYSPLASTIC syndromes; SCIENTIFIC observation; HOMOGRAFTS; GRAFT versus host disease; CONFIDENCE intervals; MULTIVARIATE analysis; LOG-rank test; CASE-control method; QUANTITATIVE research; FISHER exact test; MANN Whitney U Test; ACQUISITION of data; PATIENTS; TREATMENT failure; DISEASE relapse; RISK assessment; T-test (Statistics); SEPSIS; SURVIVAL analysis (Biometry); HEMATOLOGIC malignancies; CHI-squared test; KAPLAN-Meier estimator; DESCRIPTIVE statistics; MEDICAL records; BILE acids; SYMPTOMS; HEMATOPOIETIC stem cell transplantation; MULTIPLE myeloma; ODDS ratio; LOGISTIC regression analysis; STATISTICAL models; IMMUNOSUPPRESSIVE agents; THROMBOCYTOPENIA; TRANSPLANTATION of organs, tissues, etc.; LONGITUDINAL method; PROPORTIONAL hazards models; OVERALL survival

Objective: to analyze the factors associated with the failure of Hematopoietic Stem Cell Transplantation (HSCT) in patients undergoing Hematopoietic Stem Cell Retransplantation (HSCR). Method: this study implemented a quantitative approach and was a case-control type which addressed patients undergoing HSCR. To do so, a paired sample of two controls was used for each case (2:1). The case group consisted of the medical records of all patients who underwent HSCR (28) and the control group (56) of those who underwent only one transplant. Three variables guided the pairing: gender, diagnosis and type of transplant. Results: a total of 24 (85.71%) patients in the case group were re-transplanted due to disease relapse and four (14.29%) due to graft failure. There was a statistical difference in the analysis between patients who did not use ursodeoxycholic acid, opioid analgesics and immunosuppressants. The need for HSCR among those who used these medications inappropriately was 16.12, 12.79 and 4.5 times more likely, respectively, than those who used them correctly. Conclusion: there was a difference regarding the reasons which led to the retransplantation and the analyzed subjects, and this study concluded that the predictive reason for retransplantation in the studied sample was disease relapse. [ABSTRACT FROM AUTHOR]

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