Evaluation of Interferon Alpha (IFN-α) in Women with Systemic Lupus Erythematosus in Iraq.

تقييم انترفيرون ألفا (α-IFN )في النداء المصابات بالذئبة الحمامية الجهازية في العراق. (Arabic)

Systemic Lupus Erythematosus (SLE) is a multifactorial chronic systemic autoimmune disease. It is characterized by a lack of immune tolerance to autoantigens such as nuclear antigens. The aim of the study is to assess the interferon-alpha (IFN-α) serum level in Iraqi patients with SLE and determine its potential relation to different clinical and laboratory parameters and disease activity. 100 SLE patients were all females and with a mean of age 31.3 ± 10 years (16- 63years) and disease duration of 5.8 ± 3.7years (1 month to 15 years). The average of SLEDAI score ranged from 2 to 22 with a mean of (8.53 ±3.42). Proteinuria, ESR, creatinine and AST were significantly higher (65% vs. 10% and 0.62±0.11 vs. 0.70±0.14 mg/dl respectively) while the PLT was significantly lower (231.9±88.8 vs. 282.3±67.3 10³ /mL) (p< 0.001) among SLE patients as compared to control. Serum levels of IFN-α were increased in the SLE patients compared to control, and no significant difference has been observed (208.7±530.0 vs. 63.7±34.8 pg/ml) respectively (P=0.245). Interferon-alpha showed a significant negative correlation with the SLE Disease Activity Index (SLEDAI) in the active and inactive groups. There were no significant variations in all study parameters across IFN-α serum levels (p greater than 0.05). In conclusion, the results suggest a risk effect for female gender and age in etiology of SLE. IFN-α could not be considered as biomarker or to have a risk effect in SLE patients or perpetuate the disease activity. No evidence for any correlation between the IFN-α serum level and any clinical manifestations or laboratory investigation of the disease in current study except for age and disease duration, which suggests them as a risk factor for increasing the IFN-α serum level. [ABSTRACT FROM AUTHOR]

الذئبة الحسامية الجهازية هي مرض مشاعي ذاتي جهازي متعدد العهامل. يتسيز بشقص التحسل السشاعي لمسزادات الذاتية مثل السدتزدات الشهوية ، والهدف من الد ارسة هه تقييم مدتهى مرل مزاد لمفيروسات انترفيرون ألفا )α-IFN )في السرضى العراقيين السرابين بسرض الذئبة الحسراء وتحديد عالقته السحتسمة بسختمف العهامل الدريرية والسختبرية ونذاط السرض. 100 مريض بسرض الذئبة الحسامية السجسهعية كانها جسيعهم من اإلناث ومتهسط أعسارهم 3.31 ± 10 سشهات )16-63 سشة( ومدة السرض 8.5 ± 7.3 سشهات )من شهر واحد إلى 15 سشة(. تراوح متهسط درجات SLEDAI من 2 إلى 22 بستهسط )53.8 ± 42.3 .) كانت البيمة البروتيشية والكرياتيشين أعمى بذكل ممحهظ )65 ٪مقابل 10 ٪و 62.0 ± 11.0 مقابل 70.0 ± 14.0 مجم / ديديمتر عمى التهالي( بيشسا كان PLT أقل بذكل ممحهظ )9.231 ± 8.88 مقابل 3.282 ± 3.67 103 / مل( )001.0

Copyright of Iraqi Journal of Science is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)