Lymphotoxin-Mediated Regulation of γδCell Differentiation by αβ T Cell Progenitors.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Subject Terms:
      TUMOR necrosis factors; LYMPHOID tissue; CELL differentiation; TRANSCRIPTION factors; IMMUNE system; CELLS
    • Abstract:
      The thymus gives rise to two T cell lineages, αβ and γδ, that are thought to develop independently of one another. Hence, double positive (DP) thymocytes expressing CD4 and CD8 coreceptors are usually viewed simply as progenitors of CD4+ and CD8+ αβ T cells. Instead we report that DP cells regulate the differentiation of early thymocyte progenitors and γδ cells, by a mechanism dependent on the transcription factor RORγt, and the lymphotoxin (LT) β receptor (LTβR). This finding provokes a revised view of the thymus, in which lymphoid tissue induction-type processes coordinate the developmental and functional integration of the two T cell lineages. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)