Genetic variation and correlation of dietary response in an advanced intercross mouse line produced from two divergent growth lines.

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  • Additional Information
    • Source:
      Publisher: Cambridge University Press Country of Publication: England NLM ID: 0370741 Publication Model: Print Cited Medium: Print Linking ISSN: 00166723 NLM ISO Abbreviation: Genet Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: London ; New York : Cambridge University Press, 1960-
    • Subject Terms:
      Crosses, Genetic* ; Genetic Variation*; Dietary Fats/*pharmacology ; Mice, Inbred Strains/*genetics; Animals ; Diabetes Mellitus/genetics ; Dietary Fats/metabolism ; Female ; Male ; Mice ; Mice, Inbred Strains/growth & development ; Mice, Inbred Strains/metabolism ; Obesity/genetics ; Sex Characteristics
    • Abstract:
      Levels of human obesity have increased over the past 20 years worldwide, primarily due to changes in diet and activity levels. Although environmental changes are clearly responsible for the increasing prevalence of obesity, individuals may show genetic variation in their response to an obesogenic environment. Here, we measure genetic variation in response to a high-fat diet in a mouse model, an F16 Advanced Intercross Line derived from the cross of SM/J and LG/J inbred mouse strains. The experimental population was separated by sex and fed either a high-fat (42% of energy from fat) or low-fat (15% of energy from fat) diet. A number of phenotypic traits related to obesity and diabetes such as growth rate, glucose tolerance traits, organ weights and fat pad weights were collected and analysed in addition to serum levels of insulin, free fatty acids, cholesterol and triglycerides. Most traits are different between the sexes and between dietary treatments and for a few traits, including adult growth, fat pad weights, insulin and glucose tolerance, the dietary effect is stronger in one sex than the other. We find that fat pad weights, liver weight, serum insulin levels and adult growth rates are all phenotypically and genetically correlated with one another in both dietary treatments. Critically, these traits have relatively low genetic correlations across environments (average r =0.38). Dietary responses are also genetically correlated across these traits. We found substantial genetic variation in dietary response and low cross environment genetic correlations for traits aligned with adiposity. Therefore, genetic effects for these traits are different depending on the environment an animal is exposed to.
    • Grant Information:
      2 P60 DK20579 United States DK NIDDK NIH HHS; DK52514 United States DK NIDDK NIH HHS; DK55736 United States DK NIDDK NIH HHS; DK56341 United States DK NIDDK NIH HHS; RR15116 United States RR NCRR NIH HHS
    • Accession Number:
      0 (Dietary Fats)
    • Publication Date:
      Date Created: 20050922 Date Completed: 20060104 Latest Revision: 20081121
    • Publication Date:
      20231215
    • Accession Number:
      10.1017/S0016672305007603
    • Accession Number:
      16174340