COVID-19 and diabetes mellitus in cognitive impairment: an undrawn relationship.

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    • Alternate Title:
      COVID-19 y diabetes mellitus en el deterioro cognitivo: una relación no trazada. (Spanish)
    • Abstract:
      Cognitive impairment is a potential short- and long-term disease consequence of COVID-19 virus, the exact mechanism is still in debate. One of their potential linking is with diabetes. Diabetes and COVID-19 infection have possible multiple common mechanisms that could ensue cognitive impairment as pulmonary microthrombi (silent hypoxia); endothelial dysfunction; cerebral vascular injury oxidative stress; renin-angiotensin-aldosterone system; and galectine and interferon responses. In addition, histological markers as amyloid AB plaques and neurofibrillary tangle of Tau protein are common in both pathologies. Despite of this evidence, diabetes mellitus and COVID-19 in cognitive impairment are establishing a bright light in terms of neurological progress. This article describes the relationship between diabetes mellitus and COVID-19 as potential cause of cognitive impairment. [ABSTRACT FROM AUTHOR]
    • Abstract:
      El deterioro cognitivo es una probable consecuencia a corto y largo plazo de la enfermedad por COVID-19 cuyo mecanismo preciso aún está en discusión. Una de sus causas factibles es la diabetes. La infección por COVID-19 y la diabetes tienen múltiples posibles mecanismos comunes que podrían precipitar el deterioro cognitivo como son los micro-trombos pulmonares (hipoxia silenciosa); la disfunción endotelial; la lesión vascular cerebral inducida por estrés oxidativo; el sistema renina-angiotensina-aldosterona y la respuesta al interferón y galectina. Además, los marcadores histológicos como son las placas amiloides AB y los ovillos neurofibrilares de la proteína tau que son frecuentes en ambas patologías. A pesar de esta evidencia, la diabetes mellitus y el COVID-19 en contexto de deterioro cognitivo están dictando futuros caminos en términos de progreso neurológico. Este artículo describe la relación entre la diabetes mellitus y el COVID-19 como causa potencial de deterioro cognitivo. [ABSTRACT FROM AUTHOR]
    • Abstract:
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