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West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
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John's Island Library
9 a.m. – 8 p.m.
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Hurd/St. Andrews Library
9 a.m. – 8 p.m.
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Folly Beach Library
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Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. – 6 p.m.
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Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
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Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
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9 a.m. - 5 p.m.
Phone: (843) 805-6909
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Targeted suppression of Dpt‐specific B cells in humanized Rag2‐ γc‐ mouse model of HDM allergy.
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- Author(s): Ralchev, Nikola Ralchev (AUTHOR); Kerekov, Nikola (AUTHOR); Mihaylova, Nikolina (AUTHOR); Kremlitzka, Mariann (AUTHOR); Hristova, Diana (AUTHOR); Dzhorev, Julian (AUTHOR); Erdei, Anna (AUTHOR); Tchorbanov, Andrey Ivanov (AUTHOR)
- Source:
Scandinavian Journal of Immunology. Feb2023, Vol. 97 Issue 2, p1-14. 14p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Der p 1 is one of the major allergenic molecules of Dermatophagoides pteronyssinus, causing house dust mite (HDM) allergy. The pathological B cells produce allergen‐specific IgE antibodies that mediate the hypersensitivity reaction, therefore the selective elimination of these B cells is a legitimate therapeutic goal in allergy. Chimeric molecule Dp51‐72 able to cross‐link B cell inhibitory complement receptor type 1 and BCR on Der p 1‐specific B cells was constructed. The signalling capabilities of this molecule have been tested on human B cells. A humanized mouse model of HDM allergy has been used to test the in vivo effects of the chimeric molecule administration. Administering the chimeric molecule to immunodeficient Rag2‐ γc‐ mice transferred with PBMCs from allergic patients resulted in reduction of allergen‐specific IgE antibodies in the sera, and reduced infiltration of immune cells in lung histology preparations. Reduced numbers of human CD45+ and CD4+ cells in the lungs as well as inhibition of mast cell degranulation were also observed. The treatment with Dp51‐72 chimera significantly decreased the local levels of anti‐Dpt IgE antibodies in the bronchoalveolar lavage fluid (BALF). The binding of the chimeric molecule to tonsillar B cells triggers the tyrosine phosphorylation of 30–32 kDa protein, which is most likely involved in the inhibitory process. Administration of constructed chimeric molecules to humanized mice with developed inflammation resulted in specific suppression of disease‐associated IgE antibody‐producing cells and preserved lung histology. This effective approach could be further developed into a therapeutic agent for treatment of patients with HDM allergy. [ABSTRACT FROM AUTHOR]
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