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Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
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Otranto Road Library
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Mt. Pleasant Library
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McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
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Hurd/St. Andrews Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Phone: (843) 805-6930
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The favorable prognostic value of the loss of sex chromosomes in patients with t(8;21) acute myeloid leukemia: an exploratory study.
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- Author(s): Zhu, Lixia1 (AUTHOR); Chen, Rongrong1 (AUTHOR); Li, Xueying1 (AUTHOR); Xie, Mixue1 (AUTHOR); Yang, Xiudi1 (AUTHOR); Sun, Jianai1 (AUTHOR); Zhu, Mingyu1 (AUTHOR); Zheng, Xiaolong1 (AUTHOR); Li, Li1 (AUTHOR); Zhu, Jingjing1 (AUTHOR); Zhou, De1 (AUTHOR); Xie, Wanzhuo1 (AUTHOR); Ye, Xiujin1 (AUTHOR)
- Source:
Hematology. Dec2022, Vol. 27 Issue 1, p420-425. 6p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Acute myeloid leukemia (AML) with t(8;21) is generally associated with a favorable clinical course. Loss of sex chromosome (LOS) are frequently observed in t (8;21) AML, but the prognostic value of LOS remains uncertain. A total of 73 patients with AML with t(8;21) were studied and divided into t(8;21) with LOS group (n = 36) and t(8;21) alone group (n = 37). The patients with t(8;21) AML with ACAs other than LOS were excluded. The clinical characteristics of these two groups were compared, and the prognostic value of LOS was evaluated based on disease-free survival (DFS) and overall survival (OS). The clinical characteristics (except for gender) were found to have no significant difference between these two groups, and the male patients tended to account for a larger proportion in the former group (P =.001). The OS of the t(8;21) AML with LOS group was significantly longer than that of the t(8;21) AML alone group (P =.005). While not obvious, the patients with LOS seemed to have longer DFS (P =.061). The multivariable analysis also showed LOS to be an independent favorable prognostic factor of t(8;21) AML (P =.022). Our results suggested that LOS could be associated with a favorable prognosis in t(8;21) AML patients without other ACAs, and for this subtype of AML, longer DFS and a satisfactory and stable survival can be achieved with high-dose cytarabine (HDAC) consolidation treatment. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Hematology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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