Association of long-term exposure to ambient air pollutants with cardiac structure and cardiovascular function in Chinese adults.

Epidemiological evidence increasingly suggests that air pollutants are intimately associated with the incidence and mortality of cardiovascular diseases (CVDs). However, studies on the association between chronic exposure to air pollutants and changes in left cardiac function and structure are limited. In our cross-sectional study, 3145 participants were enrolled from 6 provinces to explore the relationship between long-term air pollutants, cardiac structure, and cardiovascular function (e.g., blood lipids, blood pressure and pulse) in Chinese adults. Our study showed that exposure to five pollutants (NO 2 , O 3 , PM 1 , PM 2.5 and PM 10) was associated with reduced left ventricular systolic function based on EF and SV parameters. These pollutants were also associated with increased pulses, where smaller particle sizes correlated significantly with pulses. Second, except for O 3 , four pollutants were associated with decreased left ventricular diastolic parameters LVIDd and EDV and increased cardiac structural parameter IVSd. In addition, exposures to NO 2 , O 3 and PM 10 were positively correlated with triglycerides in blood lipids. Overall, this study showed that chronic pollutant exposure is strongly associated with impaired left ventricular function in Chinese adults. [Display omitted] • NO 2 , O 3 and PM were associated with decline in left ventricular systolic function. • PM were associated with decrease in left ventricular diastolic function. • NO 2 and PM were associated with increased interventricular septal thickness. • NO 2 , O 3 and PM 10 was associated with increasing of TG levels. [ABSTRACT FROM AUTHOR]

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