alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid.

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  • Additional Information
    • Source:
      Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print Cited Medium: Print ISSN: 0022-3042 (Print) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE
    • Publication Information:
      Publication: 2001- : Oxford, UK : Wiley on behalf of the International Society for Neurochemistry
      Original Publication: New York : Raven Press
    • Subject Terms:
      Diet*; Brain/*metabolism ; Docosahexaenoic Acids/*administration & dosage ; Docosahexaenoic Acids/*metabolism ; Phospholipids/*metabolism ; alpha-Linolenic Acid/*administration & dosage; Animals ; Homeostasis ; Injections, Intravenous ; Lipid Metabolism ; Lipids/blood ; Male ; Osmolar Concentration ; Oxidation-Reduction ; Rats ; Rats, Inbred F344 ; Triglycerides/metabolism ; alpha-Linolenic Acid/metabolism ; alpha-Linolenic Acid/pharmacology
    • Abstract:
      Adult male unanesthetized rats, reared on a diet enriched in both alpha-linolenic acid (alpha-LNA) and docosahexaenoic acid (DHA), were infused intravenously for 5 min with [1-(14)C]alpha-LNA. Timed arterial samples were collected until the animals were killed at 5 min and the brain was removed after microwaving. Plasma and brain lipid concentrations and radioactivities were measured. Within plasma lipids, > 99% of radioactivity was in the form of unchanged [1-(14)C]alpha-LNA. Eighty-six per cent of brain radioactivity at 5 min was present as beta-oxidation products, whereas the remainder was mainly in 'stable' phospholipid or triglyceride as alpha-LNA or DHA. Equations derived from kinetic modeling demonstrated that unesterified unlabeled alpha-LNA rapidly enters brain from plasma, but that its incorporation into brain phospholipid and triglyceride, as in the form of synthesized DHA, is < or = 0.2% of the amount that enters the brain. Thus, in rats fed a diet containing large amounts of both alpha-LNA and DHA, the alpha-LNA that enters brain from plasma largely undergoes beta-oxidation, and is not an appreciable source of DHA within brain phospholipids.
    • Accession Number:
      0 (Lipids)
      0 (Phospholipids)
      0 (Triglycerides)
      0RBV727H71 (alpha-Linolenic Acid)
      25167-62-8 (Docosahexaenoic Acids)
    • Publication Date:
      Date Created: 20050812 Date Completed: 20050927 Latest Revision: 20131121
    • Publication Date:
      20221213
    • Accession Number:
      10.1111/j.1471-4159.2005.03258.x
    • Accession Number:
      16092947