[Placental proteins and protein hormones in high risk pregnancies].

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  • Author(s): Sulovic V
  • Source:
    Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka [Glas Srp Akad Nauka Med] 2002 (47), pp. 1-19.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Serbian
  • Additional Information
    • Transliterated Title:
      Proteini i proteinski hormoni placente u visoko rizicnih trudnoća.
    • Source:
      Publisher: Naucno Delo Country of Publication: Serbia NLM ID: 0027437 Publication Model: Print Cited Medium: Print ISSN: 0371-4039 (Print) Linking ISSN: 03714039 NLM ISO Abbreviation: Glas Srp Akad Nauka Med Subsets: MEDLINE
    • Publication Information:
      Original Publication: Beograd : Naucno Delo
    • Subject Terms:
      Chorionic Gonadotropin/*biosynthesis ; Placenta/*metabolism ; Pregnancy Complications/*metabolism ; Pregnancy Proteins/*biosynthesis ; Pregnancy, High-Risk/*metabolism; Female ; Humans ; In Vitro Techniques ; Placental Lactogen/biosynthesis ; Pregnancy ; Pregnancy-Specific beta 1-Glycoproteins/biosynthesis ; alpha-Fetoproteins/biosynthesis
    • Abstract:
      Experimental part of this study contains a description of an in vitro pattern of protein and protein hormones synthesis in the placental slices of various gestational ages. Incorporation of leucine -14C into placental proteins in vitro was followed-up for the purpose of measuring intensity of protein biosynthesis during pregnancy. It has been detected that the most intensive biosynthesis occurs in placentas from 6 to 8 weeks of gestation, decreases already in the 12th week, slightly increases from 22 to 24 weeks, and significantly falls at term. The same procedure was applied for the human placental lactogen (HPL) synthesis. HPL synthesis was found to be very intensive in young placentas, low in placentas from 22 to 24 weeks, and again intensive in placentas at term. The author indicates to the presence of certain yet unknown regulatory mechanisms influencing the synthesis. Concentrations of total human chorionic gonadotropins (HCG), HCG beta, HPL and beta1-glycoproteins (SP1) were determined paralelly in placentas of various gestational ages. Clinical and laboratory part of this study is dealing with the significance of dosing HPL, HCG, SP1 and alpha-fetoproteins (AFP) in various high risk pregnancies. The course of pregnancy and the obtained laboratory findings were compared with acid-base states of the newborn infants and with perinatal mortality.
    • Accession Number:
      0 (Chorionic Gonadotropin)
      0 (Pregnancy Proteins)
      0 (Pregnancy-Specific beta 1-Glycoproteins)
      0 (alpha-Fetoproteins)
      9035-54-5 (Placental Lactogen)
    • Publication Date:
      Date Created: 20050805 Date Completed: 20051012 Latest Revision: 20141120
    • Publication Date:
      20231215
    • Accession Number:
      16078438