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Kognitív működés, demencia és a menopauzális hormonterápia. (Hungarian)
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- Author(s): Ádám, László
- Source:
Magyar Nőorvosok Lapja; Dec2022, Vol. 85 Issue 6, p283-288, 6p- Subject Terms:
- Source:
- Additional Information
- Alternate Title: Cognitive function, dementia, and menopausal hormone therapy. (English)
- Abstract: The incidence of dementia and it’s most common type: Alzheimer disease is getting a matter of growing scientific and public interest. Dementia is more common among women, and the difference between genders increases after the menopausal transition. Several randomized, clinical trials have evaluated the possible effects of estrogen treatment on cognitive function and on the risk of dementia. However, data are confusing. Epidemiologic studies suggest that lifelong endogenous estrogen effect may alter cognitive function. Observational, epidemiologic studies of estrogen for the prevention of Alzheimer disease, especially in women younger than 55–60 years of age, indicated possible benefits. Meanwhile the epidemiologic support for the hypothesis that estrogen can preserve overall cognitive function in non-demented women is limited. In older women, menopausal hormone therapy (MHT) probably has no beneficiary effects on the risk of dementia. Spontaneous or iatrogenic early menopause (before 45 years of age) doubles the risk of dementia such patients should be treated with MHT for the prevention of osteoporosis and cardiovascular diseases as well. The most appropriate treatment for the symptoms of menopause syndrome is MHT. Estrogen therapy alone does not appear to be an effective treatment for Alzheimer disease however it could be useful in pharmacologic combinations. [ABSTRACT FROM AUTHOR]
- Abstract: A demencia és annak leggyakoribb formája: az Alzheimer-kór gyakori, és ma még gyógyíthatatlan betegség. Nőkben gyakoribb, mint férfiakban, és ez a nemek közötti különbség a menopauza után fokozódik. Számos epidemiológiai tanulmány támasztja alá, hogy az élethosszig tartó endogén ösztrogénhatás mértéke kapcsolatba hozható a kognitív működéssel. A 45 éves kor előtti spontán vagy iatrogén menopauza kétszeresére növeli a demencia kockázatát, ilyenkor menopauzális hormonterápia (MHT) alkalmazása szükséges. Az exogén ösztrogén, az MHT kognitív funkciókra és a demenciakockázatra való hatásával kapcsolatban az irodalom ellentmondásos: a vizsgálatok egy része szerint, különösen a 60, még inkább 55 évesnél fiatalabb páciensek esetén az MHT képes javítani bizonyos kognitív funkciókat, és csökkenteni egy későbbi Alzheimer-kór kockázatát, míg más tanulmányok ezt nem tudták megerősíteni. Az idősebb korban adott MHT nem csökkenti, de valószínűleg nem is fokozza a kockázatot, és nem gyorsítja a már kialakult Alzheimer-kór lefolyását. A már kialakult demencia kezelésére az MHT önmagában ugyan nem alkalmas, de gyógyszer-kombinációkban előnyös lehet. A menopauzaszindróma tünetei – elsősorban a hőhullámok csökkentésére – az MHT a legalkalmasabb kezelési mód, de kizárólag a demencia megelőzésére vagy kezelésére nem javasolható. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Magyar Nőorvosok Lapja is the property of Hungarian Society of Obsterics & Gynaecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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