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Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Village Library
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Association of gut‐specific non‐inflammatory T lymphocytes with chronic anorexia nervosa and constitutional thinness.
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- Author(s): Gabriel, Tristan (AUTHOR); Massoubre, Catherine (AUTHOR); Hanachi, Mouna (AUTHOR); Doré, Joel (AUTHOR); Lambert, Claude (AUTHOR); Germain, Natacha (AUTHOR); Galusca, Bogdan (AUTHOR); Paul, Stephane (AUTHOR)
- Source:
European Eating Disorders Review. Jan2023, Vol. 31 Issue 1, p76-86. 11p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Objective: Previous studies of AN showed low‐grade inflammation. Are low‐grade inflammation and circulating lymphocytes associated with chronic conditions? Method: Peripheric blood cytokines were measured using Luminex™ technology in a chronic AN cohort (mean = 67.42 months), compared to Constitutional Thinness (CT), Constitutional Obesity (CO), and Healthy Controls (HC). Secondarily a prospective cohort of chronic AN (mean = 54.11 months) was recruited to compare the functional lymphocyte profile in blood by flow cytometry to CT and HC. Results: In the AN group, most cytokine concentrations were lower than in CT and HC groups. The IL‐23 (98.02 pg/ml) was elevated related to HC and CO, and the IL‐10 (4.178 pg/ml) was elevated versus CO. In the CT group, IL‐9 (0.06216 pg/ml) was elevated compared to AN. The AN group had high Treg (9.259% of CD4+) and CD8+Integrinβ7+ (9.552% of CD3+) versus HC for lymphocyte populations. In CT group, elevated Treg (9.7% of CD4+) elevated percentage of CD4+CCR9+ (5.867% of CD3+) and CD8+Integrinβ7+ (10.21% of CD3+) were found versus HC. Conclusions: The chronic state of AN and CT is surprisingly non‐inflammatory with elevated Treg cells. These results suggest that maintaining a dysregulated response to intestinal antigens may contribute to maintaining AN. Key points: Constitutional thinness and chronic anorexia nervosa show that thinness is associated with a close immunological patternCytokine profile of constitutional thinness and chronic anorexia nervosa is not pro‐inflammatoryCirculating lymphocytes profile in constitutional thinness and anorexia nervosa is not pro‐inflammatory [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Eating Disorders Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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