"Might anti-inflammatory priming enhance the anti erectile dysfunction efficacy of pde5 inhibitors? An exploratory cohort study".

Evidences have been accruing over several years of a contributory role of low-grade systemic inflammation as a codeterminant of ED.The inflammatory interference and disruption of local microcirculation could contribute to the efficacy of PDE5i.The idea-generating pilot study herein illustrated explored if attenuating such proinflammatory contribution to the ED milieu with the help of a dietary supplement could be of benefit by enhancing the efficacy of PDE5-i Prospective cohort pilot study(14subjects with moderate ED) with end-of-study comparison of final treatment outcomes vs a random sample of ED recent historic controls from the mail author's urology ward.Cohort treatment: 1month background anti-inflammatory priming with a dietary supplement of acknowledged antiinflammatory and capillary protective properties (one 1g tablet daily) followed by 3months of alternating every-other-day treatment with 25mg sublingual sildenafil or the dietary supplement.Assessments:comparison of the overall skewness of the cohort distribution of IIEF-5 scores before and after the end of the treatment period,and purely exploratory comparison of the end-of-study EEIF-5 mean scores of the prospective cohort and the sample of historic controls Very strong left skewness of the IIEF-5 frequency distribution at the end of the study compared to the basal distribution of scores as a marker of strong efficacy;EEIF-5 mean scores,prospective active cohort vs ED historic controls:20.4 vs 14.0 There was a very strong shift of IIEF-5 scores towards an overall picture of markedly less severe or no ED in the active sample.The exploratory comparison of end-of- treatment mean IIEF-5 scores in the active cohort vs historic controls gives some preliminary idea that modifying the pro-inflammatory ED milieu with the help of the anti-inflammatory dietary supplement might indeed have contributed to the overall efficacy of the anti-ED treatment and enhanced the 3-month efficacy of sublingual sildenafil.Due to the purely hypothesis-generating nature of the study, further rigorous investigations are warranted to confirm this GDR pharma S.r.l., Milan, Italy, and its administrator, Celestino Di Rollo for providing the samples of their commercial dietary supplement with anti-inflammatory active principles [ABSTRACT FROM AUTHOR]

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