The effects of chronic nicotine on spatial learning and bromodeoxyuridine incorporation into the dentate gyrus of the rat.

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  • Author(s): Scerri C;Scerri C; Stewart CA; Breen KC; Balfour DJ
  • Source:
    Psychopharmacology [Psychopharmacology (Berl)] 2006 Mar; Vol. 184 (3-4), pp. 540-6. Date of Electronic Publication: 2005 Jul 16.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0033-3158 (Print) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin, New York, Springer-Verlag.
    • Subject Terms:
      Bromodeoxyuridine/*metabolism ; Dentate Gyrus/*drug effects ; Escape Reaction/*drug effects ; Maze Learning/*drug effects ; Mental Recall/*drug effects ; Orientation/*drug effects ; Tobacco Use Disorder/*physiopathology; Animals ; Cell Division/drug effects ; Cell Division/physiology ; DNA Replication/drug effects ; DNA Replication/physiology ; Dentate Gyrus/physiopathology ; Dose-Response Relationship, Drug ; Escape Reaction/physiology ; Male ; Maze Learning/physiology ; Mental Recall/physiology ; Neurons/drug effects ; Neurons/physiology ; Orientation/physiology ; Rats ; Rats, Sprague-Dawley
    • Abstract:
      Rationale: Nicotine is reported to improve learning and memory in experimental animals. Improved learning and memory has also been related to increased neurogenesis in the dentate gyrus (DG) of the hippocampal formation. Surprisingly, recent studies suggest that self-administered nicotine depresses cell proliferation in the DG.
      Objective: To test the hypothesis that the effects of nicotine on cell proliferation in the DG and learning and memory depend upon the nicotine dose administered.
      Methods: Rats were chronically infused from subcutaneous osmotic mini pumps with nicotine (0.25 or 4 mg kg(-1) day(-1)) or the saline vehicle for 10 days. Half the rats in each treatment group were trained to locate a hidden platform in a water maze task on days 4-7; a probe trial was performed on day 8. The remaining rats remained in their home cages. The effects of nicotine and of training in the water maze task on cell genesis in the DG were determined by measuring 5-bromo-2'-deoxyuridine (BrDU) uptake using fluorescence immunohistochemistry.
      Results: Training in the water maze task increased cell proliferation in the DG. Infusions of nicotine at 4 mg kg(-1) day(-1), but not 0.25 mg kg(-1) day(-1), decreased cell proliferation in both untrained animals and animals trained in the maze and impaired spatial learning.
      Conclusions: The data suggest that learning in the water maze task is impaired by higher doses of nicotine tested, and that this response may be related to reduced cell genesis in the DG.
    • References:
      Brain Res Brain Res Rev. 1998 May;26(2-3):198-216. (PMID: 9651527)
      Psychol Rev. 2003 Apr;110(2):285-315. (PMID: 12747525)
      Xenobiotica. 1975 Sep;5(9):553-61. (PMID: 810976)
      Neurobiol Aging. 1995 Sep-Oct;16(5):857-60. (PMID: 8532124)
      Nat Neurosci. 1999 Mar;2(3):266-70. (PMID: 10195220)
      Psychopharmacology (Berl). 1996 Jan;123(1):88-97. (PMID: 8741959)
      Brain Res. 1996 Apr 1;714(1-2):185-91. (PMID: 8861624)
      Psychopharmacology (Berl). 1998 Aug;138(3-4):217-30. (PMID: 9725745)
      Psychopharmacology (Berl). 1989;98(3):347-56. (PMID: 2526345)
      Biol Psychiatry. 2000 Jun 15;47(12):1043-9. (PMID: 10862803)
      J Neurosci Methods. 1984 May;11(1):47-60. (PMID: 6471907)
      Biol Psychiatry. 2001 Feb 1;49(3):258-67. (PMID: 11230877)
      Nature. 1982 Jun 24;297(5868):681-3. (PMID: 7088155)
      J Neurobiol. 2002 Dec;53(4):641-55. (PMID: 12436427)
      Am J Public Health. 2003 Jun;93(6):994-8. (PMID: 12773367)
      Nature. 2001 Mar 15;410(6826):372-6. (PMID: 11268214)
      J Neurosci. 1997 Apr 1;17(7):2492-8. (PMID: 9065509)
      Neuropsychobiology. 1993;28(1-2):43-6. (PMID: 8255409)
      Science. 2003 Aug 8;301(5634):805-9. (PMID: 12907793)
      Physiol Behav. 1999 Sep;67(3):421-31. (PMID: 10497962)
      Nature. 1997 Nov 27;390(6658):401-4. (PMID: 9389479)
      Behav Brain Res. 2000 Aug;113(1-2):73-83. (PMID: 10942034)
      Curr Drug Targets CNS Neurol Disord. 2002 Aug;1(4):423-31. (PMID: 12769614)
      Science. 1962 Mar 30;135(3509):1127-8. (PMID: 13860748)
      J Neurobiol. 2002 Dec;53(4):633-40. (PMID: 12436426)
      Nat Neurosci. 1999 Mar;2(3):260-5. (PMID: 10195219)
      Eur J Pharmacol. 1997 Apr 23;325(1):13-20. (PMID: 9151933)
      J Neurosci. 2000 Dec 15;20(24):9104-10. (PMID: 11124987)
      Neurochem Res. 2004 Sep;29(9):1779-92. (PMID: 15453274)
      J Neurosci. 2002 May 1;22(9):3656-62. (PMID: 11978841)
      Brain Res. 1992 Feb 14;572(1-2):281-5. (PMID: 1611524)
      Clin Investig. 1994 Feb;72(3):233-9. (PMID: 8012168)
      Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9822-6. (PMID: 15210938)
      Eur J Pharmacol. 2000 Mar 30;393(1-3):141-6. (PMID: 10771007)
      Behav Neurosci. 1990 Oct;104(5):655-65. (PMID: 2244974)
      Brain Res Dev Brain Res. 2002 Mar 31;134(1-2):13-21. (PMID: 11947933)
      Br J Pharmacol. 1995 Jan;114(2):454-60. (PMID: 7881744)
      Nat Med. 1998 Nov;4(11):1313-7. (PMID: 9809557)
      Mol Psychiatry. 2003 Nov;8(12):974-82. (PMID: 14647395)
      Nicotine Tob Res. 1999;1 Suppl 2:S143-7; discussion S165-6. (PMID: 11768172)
      Pharmacol Biochem Behav. 2000 May;66(1):65-72. (PMID: 10837844)
      Eur J Neurosci. 2003 May;17(10):2042-6. (PMID: 12786970)
      Behav Neurosci. 1998 Dec;112(6):1423-9. (PMID: 9926824)
      Psychopharmacology (Berl). 2002 Jul;162(2):129-37. (PMID: 12110990)
    • Accession Number:
      G34N38R2N1 (Bromodeoxyuridine)
    • Publication Date:
      Date Created: 20050719 Date Completed: 20061006 Latest Revision: 20181113
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/s00213-005-0086-4
    • Accession Number:
      16025316