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Balloon catheters versus vaginal prostaglandins for labour induction (CPI Collaborative): an individual participant data meta-analysis of randomised controlled trials.
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- Author(s): Jones, Madeleine N (AUTHOR); Palmer, Kirsten R (AUTHOR); Pathirana, Maleesa M (AUTHOR); Cecatti, Jose Guilherme (AUTHOR); Filho, Olimpio B Moraes (AUTHOR); Marions, Lena (AUTHOR); Edlund, Måns (AUTHOR); Prager, Martina (AUTHOR); Pennell, Craig (AUTHOR); Dickinson, Jan E (AUTHOR); Sass, Nelson (AUTHOR); Jozwiak, Marta (AUTHOR); Eikelder, Mieke Ten (AUTHOR); Rengerink, Katrien Oude (AUTHOR); Bloemenkamp, Kitty W M (AUTHOR); Henry, Amanda (AUTHOR); Løkkegaard, Ellen C L (AUTHOR); Christensen, Ib Jarle (AUTHOR); Szychowski, Jeff M (AUTHOR); Edwards, Rodney K (AUTHOR)
- Source:
Lancet. Nov2022, Vol. 400 Issue 10364, p1681-1692. 12p. - Source:
- Additional Information
- Subject Terms:
- Subject Terms:
- Abstract:
Background: Induction of labour is one of the most common obstetric interventions globally. Balloon catheters and vaginal prostaglandins are widely used to ripen the cervix in labour induction. We aimed to compare the effectiveness and safety profiles of these two induction methods.Methods: We did an individual participant data meta-analysis comparing balloon catheters and vaginal prostaglandins for cervical ripening before labour induction. We systematically identified published and unpublished randomised controlled trials that completed data collection between March 19, 2019, and May 1, 2021, by searching the Cochrane Library, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, and PubMed. Further trials done before March 19, 2019, were identified through a recent Cochrane review. Data relating to the combined use of the two methods were not included, only data from women with a viable, singleton pregnancy were analysed, and no exclusion was made based on parity or membrane status. We contacted authors of individuals trials and participant-level data were harmonised and recoded according to predefined definitions of variables. Risk of bias was assessed with the ROB2 tool. The primary outcomes were caesarean delivery, indication for caesarean delivery, a composite adverse perinatal outcome, and a composite adverse maternal outcome. We followed the intention-to-treat principle for the main analysis. The primary meta-analysis used two-stage random-effects models and the sensitivity analysis used one-stage mixed models. All models were adjusted for maternal age and parity. This meta-analysis is registered with PROSPERO (CRD42020179924).Findings: Individual participant data were available from 12 studies with a total of 5460 participants. Balloon catheters, compared with vaginal prostaglandins, did not lead to a significantly different rate of caesarean delivery (12 trials, 5414 women; crude incidence 27·0%; adjusted OR [aOR] 1·09, 95% CI 0·95-1·24; I2=0%), caesarean delivery for failure to progress (11 trials, 4601 women; aOR 1·20, 95% CI 0·91-1·58; I2=39%), or caesarean delivery for fetal distress (10 trials, 4441 women; aOR 0·86, 95% CI 0·71-1·04; I2=0%). The composite adverse perinatal outcome was lower in women who were allocated to balloon catheters than in those allocated to vaginal prostaglandins (ten trials, 4452 neonates, crude incidence 13·6%; aOR 0·80, 95% CI 0·70-0·92; I2=0%). There was no significant difference in the composite adverse maternal outcome (ten trials, 4326 women, crude incidence 22·7%; aOR 1·02, 95% CI 0·89-1·18; I2=0%).Interpretation: In induction of labour, balloon catheters and vaginal prostaglandins have comparable caesarean delivery rates and maternal safety profiles, but balloon catheters lead to fewer adverse perinatal events.Funding: Australian National Health and Medical Research Council and Monash Health Emerging Researcher Fellowship. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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