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[Mesenchymal stem cells as potential source cartilage repair].
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- Additional Information
- Transliterated Title:
A mesenchymalis ossejtek felhasználáisainak lehetoségei a porckárosodással járó mozgásszervi betegségek kezelésében.
- Source:
Publisher: Akademiai Kiado Country of Publication: Hungary NLM ID: 0376412 Publication Model: Print Cited Medium: Print ISSN: 0030-6002 (Print) Linking ISSN: 00306002 NLM ISO Abbreviation: Orv Hetil Subsets: MEDLINE
- Publication Information:
Publication: 2007- : Budapest : Akademiai Kiado
Original Publication: Pest : Markusovszky Lajos
- Subject Terms:
- Abstract:
Articular cartilage damaged by disease or trauma has a limited capacity for regeneration. The end stage of cartilage loss frequently leads to osteoarthritis resulting in a significantly decreased quality of life in millions of people. The surgical treatment of articular cartilage injury has always posed difficult problems for orthopedic surgeons and regarding long-term outcomes the currently available methods are unsatisfactory. The main lack of the applied methods is the appearance of the mechanically inadequate resident fibrocartilage instead of hyalin cartilage in the place of the cartilage defect. To find reliable methods for early repair of cartilage injuries seems of huge importance. Using techniques of tissue engineering, artificial cartilage fabricated in vitro has been applied for the repair and regeneration of damaged cartilage. Mesenchymal stem cells provide a source of cells for the repair of musculoskeletal tissue. Mesenchymal stem cells are multipotent cells that are capable of differentiating into cartilage, tendon, muscle, cartilage or hematopoiesis supporting marrow stroma. To ensure the successful durable integration and function of the engineered tissue requires suitable biomechanical and biochemical circumstances, and poses the challenge of handling in vitro culture of human cells, cell biology and molecular biology.
- Number of References:
41
- Publication Date:
Date Created: 20050707 Date Completed: 20050825 Latest Revision: 20091021
- Publication Date:
20231215
- Accession Number:
15997666
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