SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice.

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    • Abstract:
      We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection. [ABSTRACT FROM AUTHOR]