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The immune factors driving DNA methylation variation in human blood.
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- Author(s): Bergstedt, Jacob; Azzou, Sadoune Ait Kaci; Tsuo, Kristin; Jaquaniello, Anthony; Urrutia, Alejandra; Rotival, Maxime; Lin, David T. S.; MacIsaac, Julia L.; Kobor, Michael S.; Albert, Matthew L.; Duffy, Darragh; Patin, Etienne; Quintana-Murci, Lluís; Milieu Intérieur Consortium; Abel, Laurent; Alcover, Andres; Aschard, Hugues; Bousso, Philippe; Bourke, Nollaig; Brodin, Petter
- Source:
Nature Communications; 10/6/2022, Vol. 13 Issue 1, p1-20, 20p- Subject Terms:
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- Additional Information
- Abstract: Epigenetic changes are required for normal development, yet the nature and respective contribution of factors that drive epigenetic variation in humans remain to be fully characterized. Here, we assessed how the blood DNA methylome of 884 adults is affected by DNA sequence variation, age, sex and 139 factors relating to life habits and immunity. Furthermore, we investigated whether these effects are mediated or not by changes in cellular composition, measured by deep immunophenotyping. We show that DNA methylation differs substantially between naïve and memory T cells, supporting the need for adjustment on these cell-types. By doing so, we find that latent cytomegalovirus infection drives DNA methylation variation and provide further support that the increased dispersion of DNA methylation with aging is due to epigenetic drift. Finally, our results indicate that cellular composition and DNA sequence variation are the strongest predictors of DNA methylation, highlighting critical factors for medical epigenomics studies. Many studies assess epigenetic marks in white blood cells, but it is unclear how much immune factors affect the epigenome. Here, the authors show that fine-scale blood cell composition and cytomegalovirus infection affect the DNA methylome of adults. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Nature Communications is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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