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Data Mining and Network Pharmacology Analysis of Kidney-Tonifying Herbs on the Treatment of Renal Osteodystrophy Based on the Theory of "Kidney Governing Bones" in Traditional Chinese Medicine.
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- Author(s): Tong, Xue (AUTHOR); Yang, Yuanjian (AUTHOR); Gong, Shuwei (AUTHOR); Han, Xiao (AUTHOR); Wu, Yanfei (AUTHOR); Ma, Xiaoran (AUTHOR); Lang, Shuang (AUTHOR); Ma, Jianxiong (AUTHOR); Ma, Xinlong (AUTHOR)
- Source:
Evidence-based Complementary & Alternative Medicine (eCAM). 9/30/2022, p1-13. 13p. 7 Diagrams, 5 Charts, 1 Graph. - Source:
- Additional Information
- Subject Terms: ONLINE information services; COMPUTER software; HERBAL medicine; MEDICINAL plants; COMBINATION drug therapy; SYSTEMATIC reviews; RENAL osteodystrophy; ESTROGEN receptors; QUERCETIN; CELLULAR signal transduction; OSTEOPOROSIS; DRUGS; PHARMACEUTICAL chemistry; MEDLINE; COMPUTER-assisted molecular modeling; MITOGEN-activated protein kinases; DATA mining; CHINESE medicine; BONE fractures; THERAPEUTICS; DISEASE complications
- Abstract: Background. Renal osteodystrophy (ROD) secondary to chronic kidney disease is closely associated with osteoporosis and fractures. Based on the theory of "kidney governing bones" in traditional Chinese medicine (TCM), treating bone diseases from the perspective of the kidney has become a basic principle of treating ROD. However, there are many kidney-tonifying herbs and their mechanisms of treating ROD are not clear. Therefore, our study intends to use data mining and network pharmacology to study the commonly used kidney-tonifying herbs, as well as their active ingredients and mechanisms of treating ROD. Methods. We established a clinical ROD database by searching PubMed, CNKI, and other databases and screened out a core herbal combination of treating ROD. Furthermore, by using databases such as Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and GeneCards, we obtained active ingredients and targets of the core herbal combination and ROD targets. The STRING website and Cytoscape software were then used to obtain information on key active ingredients and key targets. Finally, we conducted GO and KEGG analyses using the Metascape website and molecular docking using the AutoDock Vina software. Results. Our study eventually included 58 prescriptions and 116 herbs of treating ROD. Through data mining, we found that yin-yang-huo, du-zhong, and bu-gu-zhi (YDB) constituted a core herbal combination to treat ROD. Network pharmacology showed that YDB mainly acted on targets such as estrogen receptor alpha through active ingredients such as quercetin by mitogen-activated protein kinase and other signaling pathways. Conclusion. Many ingredients, targets, and pathways are involved in the treatment of YDB for ROD. Specifically, the flavonoids contained in YDB have great potential for ROD treatment. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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